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Cardiology (Fall 2023) > trigger CV pharm > Flashcards

trigger CV pharm Flashcards

1
Q

slow rate of rise of AP and prolongs duration

A

Class 1a (Quinidine, procainamide, disopyramide)

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2
Q

shorted AP (minimal depression of phase 0 upstroke)

A

Class 1b - lidocaine, mexiletine

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3
Q

dissociates from channel with slow kinetics (no change in AP duration)

A

flexainide, propafenone

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4
Q

works as an anticholinergic on SA and AV nodes.

increases SA nodal discharge rate and AV nodal conduction

A

quinidine

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5
Q

proarrhythmic that can cause torsades via QT prolongation

A

quinidine, procainamide, disopyramide

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6
Q

similar to quinidine but lacks anticholinergic activity

A

procainamide

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7
Q

MC ADE is a clinical syndrome similar to SLE and MC use is WPW

A

procainamide

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8
Q

Potent anticholinergic and negative inotrope

A

disopyramide

CI in pts w HFrEF

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9
Q

CI in pts with HFrEF

A

Disopyramide

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10
Q

can precipitate CHF and has anticholinergic effects such as dry mouth, UR, constipation and blurred vision

A

Disopyramide

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11
Q

used for Ischemic tissue, primarily active fast sodium channels below the AV node

A

Lidocaine

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12
Q

used with ventricular dysrhythmias, especially those associated with MI

A

lidocaine

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13
Q

caution in hepatic impairement

A

lidocaine
dronedarone

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14
Q

often combined with classes Ia and III for refractory ventricular dysrhythmias

A

mexiletine

this is the oral lidocaine like drug

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15
Q

use of this medication is limited by its GI SEs

A

mexiletine

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16
Q

slows conduction velocity in the purkinje and AV node

A

flecainide

MC use is afib/aflutter

propafenone too but propafenone as has a nonselective BB effect

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17
Q

MC use is afib/aflutter

A

Flecainide

may cause rapid VT in someone w structural abnormalities

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18
Q

may cause rapid VT in someone w structural abnormalities

A

flecainide

19
Q

this drug is not used alone

A

mexiletine

20
Q

slows conduction velocity in the purkinje fibers and AV node + mild non-selective BB effect.

A

propafenone (similar to flecainide)

class 1c

21
Q

lengthens PR and QRS which can lead to bradycardia or heart block. AVOID in structural heart disease

A

propafenone

22
Q

SE of metallic taste

A

propafenone

23
Q

Contraindicated in patients w structural heart disease

A

class 1c antiarrhythmics

(flecainide and propafenone)

24
Q

Decrease automaticity, prolong AV conduction, prolong refractory period

A

beta blockers

25
Q

mainly used to suppress ventricular dysrhythmias and SVTs

A

Beta blockers

26
Q

Block potassium channels and prolong repolarization, widening QRS and prolonging QT.

A

class III antiarrhythmics

amiodarone, sotalol, dofetilide, dronedarone, ibutilide

27
Q

has characteristics of all 4 antiarrhythmic classes and works on all cells but is primarily a K+ channel blocker

A

amiodarone (class III)

28
Q

should be avoided in bradycardic patients but is also ok to use in LV dysfunction

A

amiodarone

29
Q

pts on this medication should get an annual CXR. why?

A

amiodarone

it can build up and cause pulmonary toxicity

30
Q

can induce hyper or hypothyroidism. must check TSH Q 6 months

A

amiodarone. this is because it MIMICS IODINE!!!!

31
Q

blue/gray discoloration & photosensitivity

A

amiodarone (derm toxicity)

32
Q

CYP3A4 inhibitor: can potentiate warfarin and digoxin (doubles digoxin levels)

A

amiodarone

33
Q

Primarily a potassium channel blocker but also has non-selective BB properties (negative inotrope)

A

sotalol

34
Q

Prolongs AP and QT interval. mainly atrial focused

A

dofetilide

35
Q

MC ADE is torsades (must get EKG 2 hrs after every dose)

A

dofetilide

36
Q

Similar to amiodarone with less efficacy but less SEs also

A

dronedarone

37
Q

CI: Symptomatic CHF or recent decompensation, Permanent AF

A

dronedaron

38
Q

IV only used soley for afib/aflutter cardioversion. AVOID in LV dysfunction and lyte abnormalities

A

ibutilide/corvert

39
Q

a negative inotrope that decreases automaticity and AV conduction

A

Class IV antiarrhythmics (verapamil and diltiazem.)

40
Q

Inhibition of Ca channels in AV node and activates K+ channels. slows ventricular rate in Afib/aflutter and terminates AVNRTs

A

digoxin

41
Q

PR prolongation and ST segment depression

A

digoxin

42
Q

toxicity w coadmin of ABX

A

oral digoxin

also has super poor bioavailability

43
Q

used to convert SVT to sinus rhythm

A

adenosine

44
Q

Activate potassium channel and hyperpolarizes membrane, decreasing SA node depolarization

A

adenosine

Cardiology (Fall 2023) (45 decks)

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