Hypertensive medications review Flashcards
what is the pneumonic for the classes of antihypertensive medications
ABCD
A - ACEI, ARB, Alpha Blockers
B - Beta blockers
C - Calcium Channel Blockers, Central Agonists
D - Diuretics, vasoDilators
suffix for ACE inhibitors
-pril
“lisinopril
enalapril”
suffix for ARBs
-sartan
“losartan and valsartan”
suffix for alpha blockers
-Zosin (selective)
“doxazosin and terazosin”
-Mine (nonselective)
nonselective are usually used for pheochromocytoma, so were mostly looking at selective for general HTN
suffix for beta blockers
-lol
“metoprolol and labetalol”
suffix for CCB
-dipine
“amlodipine and nicardipine”
suffix for diuretics
-ide
“furosemide and hydrochlorothiazide”
MOA for ACEi
inhibit angiotensin converting Enzyme.
This is used to convert angiotensin I to angiotensin II in the RAAS system. Angiotensin II is responsible for:
* increased vasoconstriction
* increased na+ H2O reabsorption
* increased aldosterone release
* Increased ADH release
what is the MOA of angiotensin II receptor blockers
similar to ACEi becuase they block the receptors of angiotensin II.
since angiotensin II cant bind to the receptors, it cant precipitate its effects
what is the MOA of alpha blockers
block the alpha I receptors on blood vessels so EPI and NE cannot bind to them.
alpha I receptors bind to NE and EPI and cause vascular smooth muscle contraction and vasoconstriction. This raises blood pressure.
what is the MOA of beta blockers
block beta receptors in the heart from binding to NE and EPI
when EPI and NE bind to Beta receptors in the heart, HR and SV increases causing increased CO and therefore BP.
what is the MOA of CCB? Consider the 2 different types of CCB.
blocking calcium channels on vascular and heart muscle cells.
Dihydropyridines work more on the blood vessels and work to increase vasodilation. these are more common for HTN.
Calcium entering the calcium channels causes smooth muscle contraction and vasoconstriction. CCB blocks these channels.
non-dihydropyridines work more on the heart muscle and work to decrease HR and contraction. These are more common for tachydysrhythmias but can still have an effect on BP.
what is the MOA of diuretics
inhibit or decrease water and sodium reabsorption
what is the equation for BP
what are the main effects of ACEi on BP
decreased systemic vascular resistance and stroke volume
here is the chart and a link to the video i watched! i hope this review was helpful!
https://www.youtube.com/watch?v=owcZmS5KwHw
