Treatment, Prev, Control of Viral Dz

Question 1

How does Acyclovir work? What is it used to tx?

Answer 1

It’s a analog of deoxyguanasine and it interferes w/ viral replication through competitive inhibition of viral DNA polymerase.

Tx of Herpes in humans, Feline Herpesvirus1 induced corneal ulcers, Equine herpesvirus 1 induced encephalomyelitis

Question 2

How does Amantadine work and what is it used to tx?

Answer 2

It blocks the M2 ion channel so protons can’t be pumped into endosome and virus won’t be released. It tx’s influenza A.

Question 3

What are the Neuraminidase Inhibitor drugs? What do they tx?

Answer 3

Oseltamivir (Tamiflu) 
Laninamivir
Zanamivir
Permivir
Tx: Influenza A and B viruses

Question 4

How does ZDV/AZT and ddi (Didanosine) work and what does it tx?

Answer 4

Nucleoside analog of thymine, competitive inhibition of reverse transcriptase activity. Used to tx FIV

Question 5

HIV Protease Inhibitors

Answer 5

Saquinavir
Ritonavir
Indinavir
Nelffinavir

Question 6

Live Attenuated Virus Vx can be produced in 3 ways. What are they?

Answer 6

Vx produced from naturally occurring attenuated viruses
Serial passage in cultured cells
Cold adapted mutants and reassortants

Question 7

There are two types of non-replicating Virus vx, what are they?

Answer 7

vx produced by inactivated whole virions (killed)

vx produced by purified native viral proteins

Question 8

DIVA

Answer 8

Differentiating infected animals from vx animals
Seriology- impossible
Give subunit marker vx

Question 9

Vector control

Answer 9

source reduction
biological control
chemical control

Question 10

Reducing Contact Potential

Answer 10

Isolation
Quarantine
Population Control programs

Question 11

Moist Heat Sterilization

Answer 11

Autoclave at 121C for 15 min

Question 12

Dry Heat Sterilization

Answer 12

Hot air oven for 2 hours at 160C

Question 13

What does WAHID stand for? WAHIS?

Answer 13

World Animal Health Information Database

World Animal Health Information System