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Virology Michelle > Poxviridae Part 2 > Flashcards

Poxviridae Part 2 Flashcards

1
Q

Pseudocowpox
Etiology
Epidemiology
Transmission

A

Member of the genus Parapoxvirus
Most countries
Infected cattle, milker’s hands/Teat cups, biting insects, suckling, semen of bulls

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2
Q

Pseudocowpox
Pathogenesis
Clinical Signs

A

Hyperplasia of squamous epithlemium
Acute lesions followed by scabs falling off leaving Horseshoe shaped ring of small scabs surrounding small wart like granuloma
Chronic lesions- erythema + yellow gray scabs that rub off during milking, may persist for months

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3
Q

Pseudocowpox dx

A

Horseshoe shaped ring lesion

Isolation of virus from vesicular fluid/teat skin

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4
Q

Tx of Pseudocowpox virus

A

removal of scabs, burn scabs, apply ointment before milking and astringent after milking
Prev- disinfection/iodophor teat dip. Isolate infected cows, reduce teat trauma.

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5
Q

Pseudocowpox in humans causes

A

Milker’s Nodule

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6
Q

Contagious Ecthyma
Etiology
Host
Distribution

A

Orf virus of genus Parapoxvirus
Sheep and goats, primarily lambs and kids
Worldwide

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7
Q

Transmission of Contagious Ecthyma

A

Virus survives in scabs
Infects healthy animals through infected skin
Oral lesions in lambs/kids result from nursing dams w/ teat lesions and vice versa

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8
Q

Pathogenesis of Contagious Ecthyma

A

macule-papule-vesicle-pustules-ulcers-scab formation

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9
Q

Clinical signs of Contagious Ecthyma

A

Lesions first develop in mucocutaneous junctions and there’s swelling of the lips
Lesions spread to mouth and nostrils, there may be anorexia and secondary bacterial infections. 1-4 wks scabs fall off, heal without scarring

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10
Q

T/F A malignant form of Orf/Contagious Ecthyma has been observed in sheep

A

T

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11
Q

Contagious Ecthyma vx preparation and how long do they last

A

Mix scab with saline and paint onto the inside thigh of a lamb. Check a week later for a local rxn to make sure it worked. Don’t use on a farm that doesn’t have a problem w/ Orf
Vx only last 1-2 years.

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12
Q

When should animals be vx for Contagious Ecthyma?

A

Problem herds
Lambs/Kids- 6-8 wks
Pregnant evew 7-8 wks before lambing

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13
Q

Can humans get Contagious Ecthyma

A

Yes, it causes macropapular lesions on the hands of people who handle sheep/goats, goes away after 4-9 wks

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14
Q

Sheeppox and Goatpox
Etiology
Distribution

A

member of Capripoxvirus

Endemic in Africa, Asia, parts of Europe

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15
Q

How is Sheeppox and Goatpox transmitted

A

Respiratory/Aerosol
Contaminated iatrogenic materials
Biting arthropods

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16
Q

Pathogenesis of Sheeppox

A

Incubation followed by leukocyte associated viremia
Virus localizes in skin and other internal organs.
Deposition of immune complexes results in severe necrotizing vasculitis in arterioles and postcapillary venules of the skin. Results in ishemic necrosis and of dermis and epidermis.

17
Q

Malignant form of Sheeppox

A

Incubation period is 4-8 days
Initally depressed with fever, salivation, edema of eyelids and mucopurulent nasal discharge
1-2 after pox lesions extend to pharynx larynx lungs, vagina, abomasum and spleen.
Lesions leave a star shaped scar.
Mortality 50%
Case fatality in lambs 100%

18
Q

What breeds is the Malignant form of Sheeppox seen in?

A

Lambs and nonnative breeds- Merino

19
Q

The Benign form of Sheepox is more common in _______.

What are the clinical signs?

A

adults and resistant breeds

Only skin lesions or very mild systemic rxn

20
Q

Sheeppox Prev and Control

A

Notifilable dz in most countries

Live attenuated and killed vx available, live at. works better

21
Q

Clinical signs of Goatpox

A

Reportable
Young kids- systemic dz w/ lesions on skin, respiratory and alimentary mucosae. Mild in adults.
Flat hemorrhagic form of capripox seen in some European goats and has a high case fatality.

22
Q 
Lumpy Skin Dz
Etiology
Distribution
Transmission
Host
A

Member of genus Capripoxvirus
Enzootic in sub-saharan africa and Middle East
arthropod vector and direct contact
cattle, all ages and types

23
Q

Lumpy Skin Dz
Clinical findings
Control

A

Fever, multiple nodular lesions on skin and mm, lymphadenopathy. Morbidity 80% during epzootics
Control- live att. vx. Slaughter affected/in contact animals.

24
Q 
Swinepox
Etiology
Distribution
Host
Transmission
A

genus Suipoxvirus
Worldwide
Pigs
Direct contact/skin injury, Haematopinus suis, flies/insects, transplacental

25
Q

Clinical signs and Control of Swinepox

A

transient fever
typical pox lesions on abdomen and thigs
Control- eradicate lice

26
Q 
Fowlpox
Etiology
Hosts
Distribution
Transmission
A

Avipoxvirus
poultry and turkeys
worldwide
Lives in scabs for a long time, transmitted by minor wounds and abrasions, mosquitos/lice/ticks, possibly aerosol

27
Q

What are the 3 forms of Fowlpox?

A

Cutaneous (Dry)
Diphtheric (wet)
Ocular

28
Q

Cutaneous form of Fowlpox lesions

A

Most Common form
small papules on comb, wattles and around beak
sharp fall in egg production
recovery in 4 wks

29
Q

Wet form of Fowlpox lesions

A

Droplet infection

lesions in oral mm eventually coalesce into a necrotic pseudomembrane which causes death by asphyxiation

30
Q

Clinical signs in the Ocular form of Fowlpox

A

conjunctivitis

cheesy exdate under eyelids

31
Q

What is a histopathologic finding of Avipoxvirus?

A

Borrel bodies inside Bollinger bodies

32
Q

Fowlpox Control

A

Vx either by scarification or water

Control mosquito population and other biting insects

33
Q

Ulcerative Dermatosis of Sheep
Etiology
Transmission
Clinical forms

A

Virus antigenically similar to Ecthyma virus
damaged skin or coitus
lip and leg ulceration or veneral

34
Q

Dx of Poxviruses

A

clinical signs
scrapings from skin lesions
electron microscopy

35
Q

Histopath of Poxviruses

A

Most poxviruses have slightly basophilic Type-B Guanierie inclusion bodies
Cowpox and Ectromeli have Type A/ATI inclusion bodies (eosinophilic)

36
Q

t/f Parapoxviruses grow on CAM

A

False

37
Q

What are the Parapoxviruses?

A

Pseudocowpox
Contagious Ecthyma/Orf Virus
Bovine Papular Stomatitis

Virology Michelle (11 decks)

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