Poxviridae Part 1

Question 1

Properties of Pox viruses

Answer 1

large, complex symmetry, replicates in the cytoplasm

Question 2

Antigenic characteristics of Pox viruses

Answer 2

group specific nucleoprotein
genetic recombination
hemagluttinin production by Orthopoxviruses

Question 3

Routes of transmission for Pox viruses

Answer 3

Skin, Respiratory, Mechanically by arthopods

Question 4

Spread of Pox virus

Answer 4

Pox virus usually gains access to systemic circulation via lymphatic system
Secondary viremia disseminates the virus back to the skin and other target organs

Question 5

Cowpox
Distribution
Hosts
Resivour Host

Answer 5

Endemic in Europe and Asia
Cattle, Wild and Domestic Cats, Humans, Zoo animals
Resivour- rodents

Question 6

Cowpox in Cattle
Transmission
Clinical findings

Answer 6

Milkers hand/teat cups, farm cats, rodents

Papules eventually become vesicles, vesicles rupture leaving ulcerated areas that form scabs

Question 7

Cowpox in Cats
Transmission
Clinical Signs

Answer 7

Skin innoculation, commonly rodents
Primary skin lesion, small scab or abscess
Secondary lesions widespread 7-10 days after primary lesions

Question 8

Monkeypox in humans
Transmission
Distribution
Clinical Signs

Answer 8

Primary transmission from direct contact with bodily fluids or rashes of infected animals (monkeys, Gambian rats, squirrel). Secondary transmission is human to human.
Central and West Africa
Invasion period 0-5 days with fever, lymphadenopathy
Skin eruption