Circoviridae

Question 1

Where does Circoviridae replication and is it stable?

Answer 1

Replicates in the nucleus actively dividing cells

very stable, resists 60C and pH 3-9

Question 2

Post Weaning Multisystemic Wasting Syndrome
Etiology 
Host
Distribution
Transmission

Answer 2

Porcine circovirus 2
Pigs 4-6 wks old or 2-3 wks post weaning
worldwide
fecal-oral but is found in all secretions, transplacental, fomites

Question 3

Botryoid cytoplasmic inclusion bodies within macrophages are found with what virus?

Answer 3

Porcine circovirus 2

Post Weaning Multisystemic Wasting Syndrome

Question 4

What is a consistent feature in pigs that develop clinical PMWS?

Answer 4

Lymphoid depletion and lymphopenia

Question 5

During what trimester does infection of PMWS cause abortion?

Answer 5

1st and 2nd trimester

Question 6

Clinical signs associated with PMWS

Answer 6

Subclinical most common
progressive weight loss, lethargy, slow growth, cough
Co-nfection with Porcine Parvo virus and other things can cause severe dz and more pronounced lesions

Question 7

What 2 pathogens cause Enzootic pneumonia of swine

Answer 7

PMWS and Mycoplasma hyopneumoniae

Question 8

Vx available for PMWS

When do you vx piglets? Sows?

Answer 8

Chimeric- PCV-1 (non pathogenic)
Inactivated/Baculovirul expressed vx- contain capsid proein for PCV2
Piglets- 1st dose at 3 wks old, 2nd dose 3 wks later
Sow vx- 2 and 5 wks antepartum

Question 9

Porcine Dermatitis and Nephropathy Syndrom (PDNS)

Answer 9

PCV2
Sporadic
Older piglets
Necrotizing skin lesions, vasculitis, fibrinous glomerulonephritis

Question 10

Chicken Infectious Anemia
Etiology
Host
Transmission

Answer 10

gyrovirus, family circoviridae
2-4 wk old chickens
shed in feces and feather dander, inhalation/oral exposure, vertical transmision, environmentally stable virus

Question 11

CAV replication sites

Answer 11

hemocytoblasts in bone marrow precursor T cells in cortex of thymos and dividing cd4/8 cells in spleen

Question 12

When do you vx for Chicken Infectious Anemia?

Answer 12

Live vx of antibody negative breeder flocks before the start of egg production

Question 13

Family Circoviridae general

Answer 13

Small, 17-22 nm
Circular single strand DNA 
Circo-ambisense DNA
Gyro-neg sense DNA
Non enveloped, spherical w/ icosahedral T=1
Chicken inf anemia has 12 trumpets