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Virology Michelle > Herpesviridae Part-1 > Flashcards

Herpesviridae Part-1 Flashcards

1
Q

Family Herpesviridae Viral Genome

A

Monopartite, linear, double stranded DNA
Terminal and internal reiterated repeated sequences
Have 3 types of genes, immediate early and early, late, and optional

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2
Q

Family Herpesviridae Viral Replication

A

DNA replication in nucleus
Viral envelope obtained via budding
Mature virions burst from cytoplasm released by exocytosis/cytolysis

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3
Q

What sort of inclusion bodies are characteristic of Herpesvirus

A

Type A Cowdry bodies

Eosinophilic intranuclear

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4
Q

T/F Syncitium is caused by Herpesviruses

A

True

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5
Q

What Dzs does Bovine Herpes Virus 1 Cause?

A 
Infectious Bovine Rhinotracheitis (IBR)
Infectious pustular vulvovaginitis 
Ocular form of IBR
Abortion 
Systemic Dz of Newborn Calves
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6
Q 
Bovine Herpes Virus-1
Etiology
Serotype
Subtypes
Distribution
Transmission
A 
BHV-1
Single Serotype, 3 subtypes 
1.1- respiratory
1.2 genital
1.3 encephalic
Worldwide
Droplet or Coitus/AI
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7
Q

What are the sites of latency of BHV-1?

A

Respiratory- trigeminal

Genital- Sciatic

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8
Q

Clinical Signs in BHV-1 Respiratory Form. Also what is the other name for this Dz?

A

Red Nose

Rhinitis, laryngitis, tracheitits

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9
Q

Genital Diseases associated with Bovine Herpesvirus-1

A

Infectious Pustular Vaginitis

Balanoposthitis

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10
Q

Vx for Bovine Herpesvirus-1safety in prego cows

A

Parenteral vx causes abortion in cows, intranasal does not

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11
Q 
Bovine Ulcerative mammillitis 
Etiology
Distribution
Host
Transmission
A

BHV-2
Worldwide
Cattle, heifer 2 wks after calving
direct contact via fomite or skin trauma, arthropods

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12
Q

Pseudo-Lumpy Skin Dz
Etiology
Distribution
Clinical signs

A

BHV-2
Southern Africa
Fever, nodules with depressed center, superficial dermis becomes necrotic

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13
Q

Pseudorabies/Aujesky Dz/Mad Itch
Etiology
Host

A

Porcine herpesvirus1
Primary Host- swine
Diverse range of secondary hosts

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14
Q

Pseudorabies transmission in Primary Host

A

Recovered pigs and rats act as resivours
Virus shed in saliva, nasal discharge, and milk of infected pigs
Biting,licking,aerosol, ingestion of contaminated carcass, water/feed

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15
Q

Pseduorabies transmission in Seconday Host

A

Dogs and cats- ingestion of infected pig/rat

Cattle- direct contact with infected pigs, oral/nasal routes

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16
Q

Pseudorabies in Pigs Pathogenesis

A

primary site of infection is URT
Spreads via lymph nodes
Spreads to CNS via cranial nerve axons w/preference for pons and medulla

17
Q

CNS lesions associtated with Pseudorabies in pigs

A

gangioneuritis
nonsuppurative meningioencephalitis
perivascular cuffing

18
Q

Family Herpesviridae Morphology

A 
enveloped, spherical to pleomorphic 
150-200nm
Icosohedral
162 capsomers, has tegument
Glycoproteins embedded in lipid envelope
19
Q

Clinical Signs Pseudorabies in Pigs

A

Nonimmune piglets die
nonimmune pregnant sows 50% abortion
Older piglets, growers, and adult pigs- mild dz

20
Q

Clinical signs in Pseudorabies in secondary hosts

A

Pruritis

High mortality

21
Q

Do cats generally have pruritis with Pseudorabies?

A

No, the dz progresses too rapidly

22
Q

Pseudorabies Dx

A 
History and clinical finding
Intranuclear inclusion bodies
Perivascular cuffing
Serology
PCR
23
Q

Do Pseudorabies vx prevent infection?

A

No they reduce clinical signs

24
Q

Equine Herpes Virus-1
Distribtion
Transmission

A

endemic worldwide
aerosol
direct/indirect contact with nasal discharge, aborted fetuses, placenta/placental fluids

25
Q

Where does latent EHV-1 live?

A

Trigeminal ganglia

Lymph system- lymphocytes

26
Q

Central lesion associated with EHV-1

A

infection of endothelial lining

27
Q

How does EHV-1 cause Immunosuppression?

A

EHV-1 codes for a protein that inhibits TAP, blocking antigen delivery of antigen to class I MHC molecules.

28
Q

Respiratory EHV-1

A

Younger horses
Rhinopneumonitis
Fever
Secondary bacterial infections

29
Q

Encephalomyelopathy of EHV-1

A

immune mediated vasculitis leading to infarction and hemorrhage within brain and spinal cord
can lead to lameness, quadraplegia and recombancy resulting in death

30
Q

Reproductive Form of EHV-1

A

Mostly occur in last trimester, sporadic, natural immunity lasts up to 3 years hence “abortion storms”

31
Q 
Equine Viral Rhinopnemonitis
Etiology
Distribution
Transmission
Clinical signs
A

EHV-4
Worldwide
Droplet infection
rare and sporadic, upper resp tract dz

Virology Michelle (11 decks)

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