Asfarviridae Flashcards
What animals are the resevoir for African Swine Fever?
warthogs, bush pigs and forest hogs
T/F African Swine Fever is a OIE List A Disease
T
Where is African Swine Fever endemic?
subsaharan Africa
Sardinia, Italy
Does African Swine Fever hemagglutinate?
No, but pig RBCs will adhere to the surface of virus infected cell because of a protein that appears on the plasma membrane of the infected cell during late infection.
What is the vector for African swine fever
the soft tick Ornithodorus moubata
Transmission of African Swine Fever
Sylvatic- warthog to tick
Domestic- domestic pig infected from tick, direct contact, fomites, eating pigs, aerosol, biting flies
Site of virus replication in African Swine Fever?
pharyngeal mucosa
endothelial cells
megakaryocytes
macrophages
Apoptosis mechanisms involved with African Swine Fever
p54 protein induces apoptosis
ASF infected macrophages release cytokines and apoptotic mediators
apoptosis of lymphocytes and mononuclear phagocytic cells
Clinical signs in Acute African Swine Fever
bloody, foamy nasal discharge
mm of eyes deeply congested
cutaneous hemorrhage
hyperemia of distal limbs
Clinical signs in chronic form of African Swine Fever
emaciation and stunting
swollen joints
ulcers and reddened or raised necrotic skin foci
pneumonia
Blackberry jam spleen is a hallmark of what virus?
African Swine Fever
Dx of African Swine Fever?
Hemadsorption
Virus isolation from organs
Serology, FAT, immunodiffusion
PCR
African Swine Fever
Etiology
Variation in Virulence of Virus
Host
Sole member of Family Asfarviridae
Some cause 100% mortality, other transient/inapparent infection
Domestic pigs and wild boar
