Transplant Intro (lecture)

Question 1

What is the anti-CD52 antibody covered in class?

Answer 1

Alemtuzumab - CD52 is believed to be part of lymphocyte activation

Question 2

What are the two anti-IL2 receptor antibodies covered in class?

Answer 2

Basiliximab

Dacliximab

Question 3

What are the two clacineurins covered in class?

Answer 3

Cylcosporine

Tacrolimus

Question 4

What is the MoA of Azathioprine and Mycophenolate mofetil?

Answer 4

Inhibit DNA synth and preferentially target immune system cells

Question 5

What are the two TOR (target of rapamycin) inhibitors?

Answer 5

Sirolimus

Everolimus

Question 6

What two drugs target T-cell costimulation?

Answer 6

Belatacept
Abatacept
think of the T in both of them

Question 7

Do you treat chronic rejection?

Answer 7

NO

Question 8

Do you treat acute rejection?

Answer 8

Yes

Question 9

What is the key cytokine in rejection?

Answer 9

IL-2

Question 10

What is the cause of pneumonia in immunosuppressed patients on board questions?

Answer 10

CMV

Question 11

What is the key cross matching?

Answer 11

MHC

Question 12

If in doubt, what should be the drug answered?

Answer 12

cyclosporine