SLE (lecture) Flashcards
What antibody is most sensitive for SLE?
ANA
What tow antibodies are most specific for SLE?
Anti-dsDNA and Smith
What antibody is specific for drug induced SLE?
Anti-histone
Anti SCL-70 ab is a/w _____ _____ _____.
Diffuse systemic sclerosis
What antibody is a/w CREST?
Anti-centromere
Ro and La antibodies are a/w with which diseases (2)?
SLE and Sjorgen
What antibodies associated with SLE are responsible for hyper coagulability?
Anti-phospholypid antibodies
What type of hypersensitivity is responsible for the malar rash seen in SLE?
Type II - IgG / complement reaction
Where is the skin layers are IgG deposited in SLE rashes?
Dermal - Epidermal junction
How does discoid SLE antibody testing differ from malar?
discoid usually is sDNA negative, but still ANA pos
What are the 11 criteria for SLE?
Discoid Oral ulcers Photosensitive Arthritis Malar rash Immun markers (dsDNA, Anti-Sm) Neuro involvement Elevated ESR
Renal involvement ANA + Serositis Hem involved (Hemolytic anemia, Thrombocytopenia) DOPAMINE RASH
What is the staining pattern of immuno fluorescence with glomerular SLE?
Diffuse and granular: http://www.theisn.org/education/education-topics/glomerular-disease/item/392-april2009
What 4 drugs are a/w drug induced SLE?
Hydralazine, procainamide, isoniazid, D-Penicillamine
What drug class is used in the treatment of acute flair ups of SLE?
Corticosteroid
What drug class is used in treatment of skin and organ involvement of SLE?
Anti-malarials
