HIV malignancy (lecture)

Question 1

Male with CD 4 count of 150 and multiple lesions noted on his neck. Histology of the lesion shows spindle cells in the dermal layer and diagnosis of ______ ______ is made. What is the causative agent and its genetic pathology?

Answer 1

Dx: Kaposi Sarcoma
Human Herpes Virus-8 (DNA virus)
LANA-1 inhibts p53
vCyclin blocks cyclin D --> increased G --> s
vFLIP inhibits apoptosis

Question 2

What is the first line treatment of KS?

Answer 2

Adriamycin

Question 3

What is the most common cancer of HIV patients?

Answer 3

Burkitt Lymphoma is now the most common because of the successful treatments available for KS.

Question 4

EBV is strongly associated with what types of cancer?

Answer 4

Burkitt Lymphoma

Diffuse large B cell

Question 5

Patient reports 2 weeks of malaise and has increased lymphocytes, monocytes, and basophils. On physical exam you note cervical lymphadenopathy. Histology reveals owl eye cells. What is the most likely diagnosis, related pathogen, and what type of cancer is she most at risk of developing?
Bonus: What is the buzz word for the histology finding of that cancer?

Answer 5

Mononucleosus is caused by CMV and has a risk of developing into Burkitt Lymphoma
Starry Sky is used to describe Burkitt Lymphoma

Question 6

What pathogen and its subtypes are associated with squamous cell carcinoma of the cervix? What genes are involved in it progression of Sq. CC?

Answer 6

HPV-16 and 18
E 6 blocks p53
E 7 blocks Rb function

Question 7

What is the most common form of lung cancer found in hilar lymph nodes?

Answer 7

Adenocarcinoma