HIV Comorbidity (lecture)

Question 1

What single ART Rx has the lowest association of hyperlipidemia? What is its classification and mechanism?

Answer 1

Tenofovir is a nucleoTIDE analog that results in reverse transcriptase chain termination

Question 2

What is the first line treatment of isolated high LDL?

Answer 2

Statins

Question 3

What is the first line treatment of isolated high TG?

Answer 3

Fibrate (ex. gemfibrozil, fenofibrate)

Question 4

Patient with 4 g/day proteinuria, CD4 count of 150, renal hypertrophy, hypertension. He has shown a significant increase in CD 4 counts over the past 3 months since starting ART. What classification of medication should be added? What is expected on histology of his kidneys?

Answer 4

• CKD - ACE inhibitors (-pril) are first line treatment

- IgA deposits in the mesangium and glomerular capillary wall

Question 5

What is the typical CD 4 count that leaves a patient susceptible to Mycobacterium avid-intracellulare?

Answer 5

less than 50

Question 6

What is the first line Rx treatment in osteoporosis in HIV patients?

Answer 6

Bisphosphonates (-dronates)

Question 7

What is the single most important risk factor of CVD in HIV patients?

Answer 7

Smoking

Question 8

Patient with HIV and successful ART therapy arrives with a random glucose of 220 and HbA1c of 8.0. What are the two most important treatments for controlling this patient’s DM?

Answer 8

Healthy life style (exercise and diet)

Metformin

Question 9

What is the first line treatment of isolated high LDL?

Answer 9

Statins

Question 10

What is the first line treatment of isolated high TG?

Answer 10

Fibrate (ex. gemfibrozil, fenofibrate)

Question 11

Patient with 4 g/day proteinuria, CD4 count of 150, renal hypertrophy, hypertension. He has shown a significant increase in CD 4 counts over the past 3 months since starting ART. What classification of medication should be added? What is expected on histology of his kidneys?

Answer 11

• CKD - ACE inhibitors (-pril) are first line treatment

- IgA deposits in the mesangium and glomerular capillary wall

Question 12

What is the first line Rx treatment in osteoporosis in HIV patients?

Answer 12

Bisphosphonates (-dronates)

Question 13

What is the single most important risk factor of CVD in HIV patients?

Answer 13

Smoking

Question 14

Patient with HIV and successful ART therapy arrives with a random glucose of 220 and HbA1c of 8.0. What are the two most important treatments for controlling this patient’s DM?

Answer 14

Healthy life style (exercise and diet)

Metformin