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Multisystem Midterm > ART Therapy (lecture) > Flashcards

ART Therapy (lecture) Flashcards

1
Q

What is the expected increase in CD4 counts of people on effective ART therapy?

A

2x baseline every 3 - 6 months

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2
Q

What 4 conditions may indicate deferral of ART?

A

Barriers to adherence
Co morbidities complicate ART
Elite Controllers
Long-term non-progressor

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3
Q

What are the thee strategies of ART polyRx?

A

2 x NRTI + PI
2 x NRTI + NNRTI
2 x NRTI + integrase inhibitor

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4
Q

Lamivudine, Abacavir, Tenofovir, and Emtricitabine are all examples of what class of drugs?

A

NRTI

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5
Q

Which NRTI has the highest incidence of hypersensitivity?

A

Abacavir (5%)

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6
Q

What NRTI is given as a prophylactic for vertical transmission?

A

Tenovir

Note: This is a nucleoTIDE (not side)

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7
Q

What is the most commonly prescribed NNRTI?

A

Efavirenz

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8
Q

What is an absolute contraindication of Efavirenz?

A

Pregnancy, it is teratogenic

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9
Q

What is the suffix common to all protease inhibitors?

A

-navir

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10
Q

What metabolic abnormalities are a common side effect of protease inhibitors?

A

Hyperlipidemia, Hyperglycemia

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11
Q

What protease inhibitor is synergistic with other PIs?

A

Ritonavir

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12
Q

What is the most common side effect of Indinavir?

A

Kidney stones (made of the drug itself)

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13
Q

What dietary restriction is indicated in Atazanavir use?

A

Milk may inhibit absorption

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14
Q

What is the first line protease inhibitor?

A

Darunavir

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15
Q

What is the MoA of Enfuvirtide?

A

Fusion inhibitor (enFUvirtide prevents inFUsion) by blocking gp41

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16
Q

What is the MoA of Maraviroc?

A

Inhibits binding of HIV to CCR5 (maraviROC blocks binding)

17
Q

What is the common suffix of integrase inhibitors?

A

-gravir

Raltegravire, Dolutegravir

18
Q

What are the ARTs, from least to most commonly used?

A

HaHa. Just kidding. This changes too much for it to be tested. If you want to know, look at the lecture.

19
Q

What is the immediate treatment given to neonates from an HIV + mother?

A

Ziduvudine (AZT)

20
Q

What class of drugs are notorious for lactic acidosis as a side effect?

A

NRTIs

Multisystem Midterm (22 decks)

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