Tranexamic Acid (TXA) - Antifibrinolytic

Question 1

What is the concentration of Tranexamic Acid (TXA) when it is diluted for administration?
Select all that apply.

A) 2000 mg/200 mL
B) 1000 mg/100 mL
C) 2000 mg/250 mL
D) 1000 mg/200 mL

Answer 1

A) 2000 mg/200 mL

Question 2

If a patient weighs 70 kg, how much Tranexamic Acid (TXA) should be administered during the loading phase?
Select all that apply.

A) 70 mL over 30 minutes
B) 100 mL over 30 minutes
C) 7 mL/hr as the maintenance dose
D) 10 mg/kg over 30 minutes

Answer 2

A) 70 mL over 30 minutes
D) 10 mg/kg over 30 minutes

2000 mg/200 mL
Load 10 mg/kg over 30 minutes (70kg=70mL)
Run 1 mg/kg/hr (7 mL/hr)

Question 3

What is the maintenance dose rate for Tranexamic Acid (TXA)?

A) 1 mg/kg/hr
B) 0.5 mg/kg/hr
C) 5 mg/kg/hr
D) 7 mL/hr

Answer 3

A) 1 mg/kg/hr

Load 10 mg/kg over 30 minutes (70kg=70mL)
Run 1 mg/kg/hr (7 mL/hr)

Question 4

What is the mechanism of action (MOA) of Tranexamic Acid (TXA)?
Select 2

A) Inhibits the activation of plasminogen to plasmin
B) Enhances the conversion of plasminogen to plasmin
C) Helps preserve the integrity of the fibrin clot
D) Promotes the degradation of fibrin clots

Answer 4

A) Inhibits the activation of plasminogen to plasmin

C) Helps preserve the integrity of the fibrin clot

MOA: Inhibits activation of plasminogen to plasmin, an enzyme that degrades fibrin clots. (Helps preserve the integrity of the fibrin clot)

Question 5

What should be done to avoid hypotension when administering Tranexamic Acid (TXA)?

A) Administer Tranexamic Acid (TXA) slowly
B) Administer Tranexamic Acid (TXA) rapidly to achieve quick results
C) Monitor blood pressure closely during administration
D) Administer with a vasoconstrictor to counteract hypotension

Answer 5

A) Administer Tranexamic Acid (TXA) slowly

ADMINISTER SLOW TO AVOID HYPOTENSION!!