Methylene Blue

Question 1

What is the recommended dose of Methylene Blue?

A) 0.5 mg/kg
B) 1 mg/kg
C) 1.5 mg/kg
D) 2 mg/kg

Answer 1

C) 1.5 mg/kg

Question 2

Methylene Blue is supplied in which concentration?

A) 50 mg per vial
B) 100 mg per vial
C) 150 mg per vial
D) 200 mg per vial

Answer 2

B) 100 mg per vial

Question 3

In which clinical scenario is Methylene Blue most useful?

A) Vasoplegic hypotension with adequate volume and pressors post-cardiopulmonary bypass
B) Hypertension during cardiopulmonary bypass
C) Acute management of myocardial infarction
D) Hypotension due to hypovolemia

Answer 3

A) Vasoplegic hypotension with adequate volume and pressors post-cardiopulmonary bypass

Useful for vasoplegic heart, adequate volume/adequate pressors/hypotensive coming off pump.

Question 4

What is the mechanism of action (MOA) of Methylene Blue?

Select 2:

A) Inhibits guanylate cyclase (GC)
B) Prevents the release of nitric oxide (NO)
C) Activates potassium channels in endothelial cells
D) Increases cyclic GMP to promote vasodilation

Answer 4

A) Inhibits guanylate cyclase (GC)
B) Prevents the release of nitric oxide (NO)

Question 5

Which of the following is an alternate treatment to Methylene Blue for vasoplegic hypotension?

A) Hydroxocobalamin 5 grams
B) Albuterol 2.5 mg nebulized
C) Phenylephrine 100 mcg IV push
D) Dobutamine 5-20 mcg/kg/min

Answer 5

A) Hydroxocobalamin 5 grams

Question 6

What is the mechanism of action (MOA) of Hydroxocobalamin 5gm in treating vasoplegic hypotension?

Select 2:

A) Acts on hydrogen sulfide and nitric oxide pathways
B) Affects potassium channels in endothelial cells
C) Inhibits guanylate cyclase (GC)
D) Enhances vasodilation by increasing NO release

Answer 6

A) Acts on hydrogen sulfide and nitric oxide pathways
B) Affects potassium channels in endothelial cells