Desmopressin (DDVAP)

Question 1

What is the correct infusion dose of Desmopressin (DDAVP) for hemostatic support?

A) 0.1 mg/kg over 10 minutes
B) 0.3 mg/kg over 15-30 minutes
C) 1 mg/kg over 1 hour
D) 0.5 mg/kg over 5 minutes

Answer 1

B) 0.3 mg/kg over 15-30 minutes

Question 2

What are the onset and duration of action (DOA) for Desmopressin (DDAVP)? Select 2

A) Onset: <1-2 minutes
B) Onset: 5-10 minutes
C) Duration of Action: 30 minutes
D) Duration of Action: 2.5-4.5 hours

Answer 2

A) Onset: <1-2 minutes
D) Duration of Action: 2.5-4.5 hours

Question 3

What is the mechanism of action (MOA) of Desmopressin (DDAVP) in minimizing blood loss?

Select 2:

A) Stimulates the release of von Willebrand factor (vWF)
B) Inhibits fibrinolysis to maintain clot integrity
C) Promotes platelet adherence to the vascular subendothelium
D) Binds to heparin to reverse anticoagulation

Answer 3

A) Stimulates the release of von Willebrand factor (vWF)

C) Promotes platelet adherence to the vascular subendothelium

MOA: Stimulates the release of vWF. vWF mediates platelet adherence to vascular subendothelium to shorten the bleeding time (minimize blood loss) in cardiac surgery, as well as patients with mild forms of hemophilia A or von Willebrand’s disease (VWD).

Question 4

For which conditions is Desmopressin (DDAVP) most useful?

Select 2y:

A) Type 3 von Willebrand Disease (VWD)
B) Hemophilia B
C) Uremic bleeding with platelet dysfunction
D) Severe thrombocytopenia

Answer 4

A) Type 3 von Willebrand Disease (VWD)

C) Uremic bleeding with platelet dysfunction

Most useful in type 3 VWD

Indicated for UREMIC bleeding (platelet dysfunction)

Question 5

What is a critical consideration when administering Desmopressin (DDAVP) to avoid adverse effects? Select 3

A) Administer slowly to avoid hypotension
B) Dilute in a 50 mL bag and infuse over 15-30 minutes
C) Ensure protamine is administered first when used after cardiac surgery
D) Administer as a rapid IV push for quicker effect

Answer 5

A) Administer slowly to avoid hypotension
B) Dilute in a 50 mL bag and infuse over 15-30 minutes
C) Ensure protamine is administered first when used after cardiac surgery

Admin SLOW to avoid hypotension because it stimulates endothelial cells, releasing vasoactive mediators (in add’n to vWF).

Question 6

Why should Desmopressin (DDAVP) be administered slowly?

Select 2:

A) To avoid hypotension caused by rapid vasodilation
B) To prevent reflex tachycardia
C) Because it stimulates endothelial cells to release vasoactive mediators
D) To enhance the efficacy of von Willebrand factor (vWF) release

Answer 6

A) To avoid hypotension caused by rapid vasodilation

C) Because it stimulates endothelial cells to release vasoactive mediators

Admin SLOW to avoid hypotension because it stimulates endothelial cells, releasing vasoactive mediators (in add’n to vWF).

Question 7

What specific steps should be taken before administering Desmopressin (DDAVP) for hemostatic purposes?

Select 2:

A) Contact the pharmacy to mix the dose for infusion
B) Infuse rapidly to minimize bleeding risk
C) Administer the infusion over 15 minutes
D) Combine with protamine administration to enhance clot stability

Answer 7

A) Contact the pharmacy to mix the dose for infusion

C) Administer the infusion over 15 minutes

Call pharmacy to mix—give infusion over 15 minutes (vasodilation)