Heparin Flashcards
What is the correct dosing guideline for Heparin when given intravenously for anticoagulation?
A) 4 mg/kg
B) 400 u/kg
C) 1 mg/kg
D) 100 u/kg
A) 4 mg/kg
In Heparin dosing, what is the equivalent unit-to-milligram conversion?
A) 50 units = 1 mg
B) 100 units = 1 mg
C) 10 units = 1 mg
D) 1 unit = 1 mg
B) 100 units = 1 mg
Which of the following is true about Heparin’s mechanism of action?
A) Heparin activates antithrombin III, inhibiting thrombin and factor Xa
B) Heparin directly inhibits platelet aggregation
C) Heparin is a direct thrombin inhibitor
D) Heparin binds to fibrinogen to prevent clot formation
A) Heparin activates antithrombin III, inhibiting thrombin and factor Xa
What is the target Activated Clotting Time (ACT) for patients on Heparin on pump?
A) 300 seconds
B) 250 seconds
C) 400-480 seconds
D) 500-600 seconds
C) 400-480 seconds
What is the target Activated Clotting Time (ACT) for patients off-pump while receiving Heparin?
A) 300 seconds
B) 400-480 seconds
C) 250 seconds
D) 500-600 seconds
A) 300 seconds
In a patient undergoing off-pump cardiac surgery, if the Heparin resistance is suspected due to low antithrombin III levels, which treatments are recommended?
Select 2:
A) Administer FFP (2 unitw)
B) Administer Thrombate III
C) Increase Heparin infusion
D) Administer Protamine
A) Administer FFP (2)
B) Administer Thrombate III
If they are resistant they could be antithrombin III low, treatment to give FFP (2) or Thrombate III: peak 20 min, get from Pharmacy Main, must be refrigerated 77 (F) 500 IU, cost $3.50/unit
When using Thrombate III to address Heparin resistance, what is the typical peak time for this treatment?
A) 5 minutes
B) 10 minutes
C) 20 minutes
D) 1 hour
C) 20 minutes
What important considerations should be kept in mind when using Thrombate III to treat Heparin resistance?
Select 2
A) Must be refrigerated at 77°F
B) Cost is approximately $3.50 per unit
C) Peak effect occurs within 5 minutes
D) Requires no specific mixing instructions
A) Must be refrigerated at 77°F
B) Cost is approximately $3.50 per unit
In the case of Heparin allergy due to anti-PF4 antibodies and thrombocytopenia, which alternative anticoagulant is recommended?
A) Argatroban
B) Heparin
C) Warfarin
D) Enoxaparin
A) Argatroban
For a patient with Heparin-induced thrombocytopenia (HIT) and a confirmed allergy, the recommended loading dose of Argatroban is:
Select all that apply:
A) 5 mcg/kg
B) 10 mcg/kg
C) 20 mcg/kg
D) 30 mcg/kg
B) 10 mcg/kg
When administering Argatroban in a patient with Heparin allergy, the typical infusion rate after loading is:
A) 1-2 mcg/kg/min
B) 3-6 mcg/kg/min
C) 10-12 mcg/kg/min
D) 15-20 mcg/kg/min
B) 3-6 mcg/kg/min
What is the half-life of Argatroban, and how does this impact its clinical use?
Select 2:
A) Half-life: 45 minutes
B) Half-life: 2 hours
C) It has a short half-life
D) It has a long half-life
A) Half-life: 45 minutes
C) It has a short half-life
