Epinephrine (B1, B2, Alpha 1 Agonist) Flashcards
What is the correct IV push dose range for Epinephrine?
A. 1-2 mcg
B. 5-10 mcg
C. 20-30 mcg
D. 50-100 mcg
Answer: B. 5-10 mcg
What is the concentration of a low-dose stick of Epinephrine?
A. 100 mcg/mL
B. 1 mg/mL
C. 10 mcg/mL
D. 50 mcg/mL
C. 10 mcg/mL
Low-dose stick: 10 mcg/mL
1mL of strong stick (100mcg/mL) in 9mL = 10mcg/mL
How is a strong stick of Epinephrine prepared for IV push administration?
A. 100 mcg/mL
B. 10 mcg/mL
C. 50 mcg/mL
D. 1 mg/mL
A. 100 mcg/mL
Strong stick: 100 mcg/mL
1mg in 9mL = 100 mcg/mL
What is the correct infusion dose range for low-dose Epinephrine (beta stimulation)?
A. 0.01-0.02 mcg/kg/min
B. 0.03-0.1 mcg/kg/min
C. 0.1-0.2 mcg/kg/min
D. 0.2-0.3 mcg/kg/min
A. 0.01-0.02 mcg/kg/min
What is the concentration of Epinephrine in a continuous infusion for use in a pump?
A. 10 mcg/mL
B. 16 mcg/mL
C. 100 mcg/mL
D. 50 mcg/mL
B. 16 mcg/mL (4 mg/250 mL)
What is the onset of action for IV Epinephrine?
A. Less than 30 seconds
B. Less than 1 minute
C. 1-2 minutes
D. 5 minutes
B. Less than 1 minute
What is the peak time of action for IV Epinephrine?
A. 30 seconds
B. 1-2 minutes
C. 5-10 minutes
D. 15 minutes
B. 1-2 minutes
What is the duration of action (DOA) for IV Epinephrine?
A. 1-2 minutes
B. 5-10 minutes
C. 15-20 minutes
D. 30 minutes
Answer: B. 5-10 minutes
What is the primary mechanism of action (MOA) of Epinephrine at low doses?
A. Alpha-1 receptor stimulation
B. Beta receptor stimulation
C. Nonselective alpha and beta blockade
D. Muscarinic receptor stimulation
Answer: B. Beta receptor stimulation
MOA: Potent alpha & beta stimulation ⇒ ↑SV + ↑HR
Low dose: Beta
● ↑HR, CO, CTX, PP
● ↓SVR
What effect does Epinephrine have at high doses (0.15-0.3 mcg/kg/min)?
A. Decreased systemic vascular resistance (SVR)
B. Increased systemic vascular resistance (SVR) and decreased cardiac output (CO)
C. Increased heart rate (HR) only
D. Decreased blood glucose levels
B. Increased systemic vascular resistance (SVR) and decreased cardiac output (CO)
MOA: Potent alpha & beta stimulation ⇒ ↑SV + ↑HR
Low dose: Beta
● ↑HR, CO, CTX, PP
● ↓SVR
High dose: Alpha
● ↑SVR & ↓CO
What is the correct Epinephrine dosing range for beta receptor stimulation?
A. 0.01-0.03 mcg/kg/min
B. 0.03-0.15 mcg/kg/min
C. 0.15-0.3 mcg/kg/min
D. 0.5-1 mcg/kg/min
A. 0.01-0.03 mcg/kg/min
At what infusion rate does Epinephrine stimulate both alpha and beta receptors?
A. 0.01-0.03 mcg/kg/min
B. 0.03-0.15 mcg/kg/min
C. 0.15-0.3 mcg/kg/min
D. 0.5 mcg/kg/min
B. 0.03-0.15 mcg/kg/min
What is a potential cardiovascular risk associated with high doses of Epinephrine?
A. Myocardial ischemia due to increased oxygen demand
B. Decreased myocardial oxygen consumption
C. Hypotension and bradycardia
D. Increased oxygen supply to the myocardium
A. Myocardial ischemia due to increased oxygen demand
May produce myocardial ischemia.
+inotropy & tachycardia ⇒ ↑O2 demand & ↓O2 supply
What is the correct infusion dose range for primarily alpha receptor stimulation by Epinephrine?
A. 0.01-0.03 mcg/kg/min
B. 0.03-0.1 mcg/kg/min
C. 0.15-0.3 mcg/kg/min
D. 0.3-0.5 mcg/kg/min
C. 0.15-0.3 mcg/kg/min
Why does Epinephrine increase blood glucose levels?
A. Increased insulin secretion and decreased glucagon release
B. Decreased liver glycogenolysis and increased glucagon release
C. Increased liver glycogenolysis, increased glucagon, and decreased insulin release
D. Decreased glycogenolysis and decreased glucagon secretion
C. Increased liver glycogenolysis, increased glucagon, and decreased insulin release
SE: HypoK & ↑BG & Accelerates coagulation
↑blood glucose d/t inc liver glycogenolysis, inc glucagon, dec release insulin
