Isoproterenol - Pure Beta Adrenergic Agonist (may only be seen with cath lab patients) Flashcards
What is the appropriate range for the infusion rate of Isoproterenol for clinical use?
A) 1-10 mcg/min
B) 1-20 mcg/min
C) 5-25 mcg/min
D) 10-30 mcg/min
B) 1-20 mcg/min
What is the concentration of Isoproterenol?
A) 4 mcg/mL
(200mcg in 50 mL)
B) 5 mcg/mL
(250mcg in 50 mL)
C) 10 mcg/mL
(1000 mcg/100mL)
4 mcg/mL concentration
(200mcg in 50 mL)
What is the onset time for Isoproterenol when administered intravenously?
A) <1 minute
B) 1-2 minutes
C) 3-5 minutes
D) 10 minutes
Answer: A) <1 minute
At what time does Isoproterenol typically reach its peak effect after intravenous administration?
A) <1 minute
B) 1-2 minutes
C) 3-5 minutes
D) 10 minutes
Answer: B) 1-2 minutes
What is the duration of action (DOA) of Isoproterenol following intravenous administration?
A) 5-10 minutes
B) 10-15 minutes
C) 20-30 minutes
D) 45 minutes
Answer: B) 10-15 minutes
Isoproterenol is known for its beta-sympathomimetic activity. Which type of receptors does it primarily target?
A) Beta-1 receptors only
B) Beta-2 receptors only
C) Selective Beta-1 but some Beta-2 receptors
D) Alpha-1 receptors only
C) Selective Beta-1 but some Beta-2 receptors
MOA: Beta-sympathomimetic, selective Beta 1, but has some Beta 2 that acts on heart, bronchial smooth muscle skeletal muscle, and alimentary tract.
Which of the following is NOT a target tissue affected by Isoproterenol?
A) Heart
B) Bronchial smooth muscle
C) Skeletal muscle
D) Gastric mucosa
Answer: D) Gastric mucosa
MOA: Beta-sympathomimetic, selective Beta 1, but has some Beta 2 that acts on heart, bronchial smooth muscle skeletal muscle, and alimentary tract.
Isoproterenol is indicated for use in situations where increased inotropy is needed and tachycardia isn’t detrimental. Which of the following conditions is a suitable indication for Isoproterenol? (Select 2)
A) Severe bradycardia with a functional AV node
B) Low cardiac output with no need for inotropy
C) AV block or a denervated heart
D) Pulmonary hypertension or RV dysfunction
Answer: C) AV block or a denervated heart
D) Pulmonary hypertension or RV dysfunction
Indicated for low CO, especially in situations where increased inotropy is needed & tachycardia isnt detrimental:
● AV block or a denervated heart
● Pulm HTN or RV dysfunction
Which of the following mechanisms does Isoproterenol use to increase cardiac output (CO)?
A) Decreasing heart rate (HR)
B) Decreasing myocardial contractility (CTX)
C) Increasing systemic vascular resistance (SVR)
D) Increasing heart rate (HR), increasing myocardial contractility (CTX), and decreasing systemic vascular resistance (SVR)
D) Increasing heart rate (HR), increasing myocardial contractility (CTX), and decreasing systemic vascular resistance (SVR)
Increases CO via 3 mechanisms: ↑HR, ↑CTX, ↓SVR
● Increase: SBP, HR, CO/CI, and PAP
● Decrease: MAP, SVR and PVR