Isoproterenol - Pure Beta Adrenergic Agonist (may only be seen with cath lab patients)

Question 1

What is the appropriate range for the infusion rate of Isoproterenol for clinical use?

A) 1-10 mcg/min
B) 1-20 mcg/min
C) 5-25 mcg/min
D) 10-30 mcg/min

Answer 1

B) 1-20 mcg/min

Question 2

What is the concentration of Isoproterenol?

A) 4 mcg/mL
(200mcg in 50 mL)

B) 5 mcg/mL
(250mcg in 50 mL)

C) 10 mcg/mL
(1000 mcg/100mL)

Answer 2

4 mcg/mL concentration
(200mcg in 50 mL)

Question 3

What is the onset time for Isoproterenol when administered intravenously?

A) <1 minute
B) 1-2 minutes
C) 3-5 minutes
D) 10 minutes

Answer 3

A) <1 minute

Question 4

At what time does Isoproterenol typically reach its peak effect after intravenous administration?

A) <1 minute
B) 1-2 minutes
C) 3-5 minutes
D) 10 minutes

Answer 4

B) 1-2 minutes

Question 5

What is the duration of action (DOA) of Isoproterenol following intravenous administration?

A) 5-10 minutes
B) 10-15 minutes
C) 20-30 minutes
D) 45 minutes

Answer 5

B) 10-15 minutes

Question 6

Isoproterenol is known for its beta-sympathomimetic activity. Which type of receptors does it primarily target?

A) Beta-1 receptors only
B) Beta-2 receptors only
C) Selective Beta-1 but some Beta-2 receptors
D) Alpha-1 receptors only

Answer 6

C) Selective Beta-1 but some Beta-2 receptors

MOA: Beta-sympathomimetic, selective Beta 1, but has some Beta 2 that acts on heart, bronchial smooth muscle skeletal muscle, and alimentary tract.

Question 7

Which of the following is NOT a target tissue affected by Isoproterenol?

A) Heart
B) Bronchial smooth muscle
C) Skeletal muscle
D) Gastric mucosa

Answer 7

Answer: D) Gastric mucosa

MOA: Beta-sympathomimetic, selective Beta 1, but has some Beta 2 that acts on heart, bronchial smooth muscle skeletal muscle, and alimentary tract.

Question 8

Isoproterenol is indicated for use in situations where increased inotropy is needed and tachycardia isn’t detrimental. Which of the following conditions is a suitable indication for Isoproterenol? (Select 2)

A) Severe bradycardia with a functional AV node
B) Low cardiac output with no need for inotropy
C) AV block or a denervated heart
D) Pulmonary hypertension or RV dysfunction

Answer 8

Answer: C) AV block or a denervated heart
D) Pulmonary hypertension or RV dysfunction

Indicated for low CO, especially in situations where increased inotropy is needed & tachycardia isnt detrimental:
● AV block or a denervated heart
● Pulm HTN or RV dysfunction

Question 9

Which of the following mechanisms does Isoproterenol use to increase cardiac output (CO)?

A) Decreasing heart rate (HR)
B) Decreasing myocardial contractility (CTX)
C) Increasing systemic vascular resistance (SVR)
D) Increasing heart rate (HR), increasing myocardial contractility (CTX), and decreasing systemic vascular resistance (SVR)

Answer 9

D) Increasing heart rate (HR), increasing myocardial contractility (CTX), and decreasing systemic vascular resistance (SVR)

Increases CO via 3 mechanisms: ↑HR, ↑CTX, ↓SVR
● Increase: SBP, HR, CO/CI, and PAP
● Decrease: MAP, SVR and PVR