Trace and Toxic Elements

Question 1

Extreme copper deficiency is seen in what fatal condition?
a. Menkes’ disease
b. Klinefelter’s syndrome
c. Meese disease
d. Kayser-Fleischer rings

Answer 1

a. Menkes’ disease

Question 2

Suppose the controller on a GFAAS is defective and the furnace is running
cold. What effect will this likely have on the number of photons absorbed
in the measurements?
a. It will decrease the number of photons absorbed.
b. It will increase the number of photons absorbed.
c. It will have little effect.
d. It is not a relevant question because AAS relies on emission of light
from electronically excited atoms.

Answer 2

a. It will decrease the number of photons absorbed.

Question 3

. Why would a clinical chemist develop an arsenic method that combines liquid
chromatography with ICP-MS?
a. To separate and quantitate several different arsenic-containing species
in the same sample
b. To eliminate interference by sodium from the analysis
c. To shorten the run time of the measurement
d. To lower the coefficient of variation for total arsenic measurements

Answer 3

a. To separate and quantitate several different arsenic-containing species
in the same sample

Question 4

Select the answer that designates three techniques widely used for elemental
analysis, identified according to the initials for the techniques.
a. AAS, ICP-MS, AES
b. NMR, ICP-MS, AES
c. GC-MS, ICP-MS, AES
d. HPLC-ICP-MS, AAS, FTIR

Answer 4

a. AAS, ICP-MS, AES

Question 5

One of the calcium isotopes (
40Ca) has an atomic weight of 40. At what
positions in a mass spectrum would singly and doubly charged ions of this
isotope of calcium appear? Assume that singly charged Ca is listed first.
a. 40 and 20
b. 40 and 60
c. 40 and 80
d. 40 and 40

Answer 5

a. 40 and 20

Question 6

. What primary purposes does the torch serve in ICP-MS?
a. Vaporization, atomization, and ionization
b. Vaporization, atomization, and electronic excitation
c. Nebulization, atomization, and photon absorption
d. Droplet transport, vaporization, and ion detection

Answer 6

a. Vaporization, atomization, and ionization

Question 7

. Manganese toxicity resembles the following disease:
a. Parkinson’s disease
b. Wilson’s disease
c. Alzheimer’s disease
d. Menkes’ disease

Answer 7

a. Parkinson’s disease

Question 8

Iron is physiologically active only in the ferrous form in
a. Hemoglobin
b. Cytochromes
c. Ferritin
d. Transferrin

Answer 8

a. Hemoglobin

Question 9

A metal ion required for optimal enzyme activity is best termed a(an)
a. Cofactor
b. Accelerator
c. Coenzyme
d. Catalyst

Answer 9

a. Cofactor

Question 10

Which trace metal is contained in glucose tolerance factor?
a. Chromium
b. Copper
c. Selenium
d. Zinc

Answer 10

a. Chromium

Question 11

What metal may be used as a treatment for Wilson’s disease?
a. Zinc
b. Copper
c. Molybdenum
d. Fluorine

Answer 11

a. Zinc

Question 12

The metal ion essential for the activity of xanthine oxidase and xanthine
dehydrogenase is
a. Molybdenum
b. Iron
c. Zinc
d. Manganese

Answer 12

a. Molybdenum