Lipids and Lipoproteins Flashcards
Which of the following methods for lipoprotein electrophoresis depends on
charge and molecular size?
a. Polyacrylamide gel
b. Paper
c. Cellulose acetate
d. Agarose
a. Polyacrylamide gel
Which of the following statements concerning chylomicrons is FALSE?
a. The major lipid transported by this lipoprotein is cholesterol.
b. This lipoprotein is produced in the intestinal mucosa.
c. The primary function is to carry dietary (exogenous) lipids to the liver.
d. It remains at the origin (point of application) during lipoprotein
electrophoresis.
a. The major lipid transported by this lipoprotein is cholesterol.
The lipoprotein that contains the greatest amount of protein is called
a. HDL
b. Chylomicrons
c. VLDL
d. LDL
a. HDL
True or False? Pre–beta (VLDL)-lipoproteins migrate further toward the
anode on polyacrylamide gel than they do on cellulose acetate or agarose.
False
Several enzymatic triglyceride methods measure the production or consumption of
a. NADH
b. Fatty acids
c. Glycerol
d. Diacetyl lutidine
c. Glycerol
The most likely cause for serum/plasma to appear “milky” is the presence of
a. Chylomicrons
b. VLDL
c. LDL
d. HDL
a. Chylomicrons
. In the colorimetric determination of cholesterol using the enzyme cholesterol
oxidase, the agent that oxidizes the colorless organic compound 4-
aminoantipyrine to a pink complex is
a. Hydrogen peroxide
b. Cholest-4-ene-3-one
c. NAD
d. Phenol
a. Hydrogen peroxide
Which lipoprotein is the major carrier of cholesterol to peripheral tissue?
a. LDL
b. Chylomicrons
c. VLDL
d. HDL
a. LDL
True or false? Increased levels of apo A-I are associated with increased risk of
CAD.
False
A patient is admitted to the hospital with intense chest pains. The patient’s
primary care physician requests the emergency department doctor to order
several tests, including a lipid profile with cholesterol fractionation. Given
the patient’s results provided below, what would be the LDL-C for this
patient?
Total cholesterol = 400 mg/dL; triglycerides = 300 mg/dL; HDL-C = 100
mg/dL; LP electrophoresis, pending.
a. 240 mg/dL
b. 160 mg/dL
c. 200 mg/dL
d. 300 mg/dL
a. 240 mg/dL
A patient is admitted to the hospital with intense chest pains. The patient’s
primary care physician requests the emergency department doctor to order
several tests, including a lipid profile with cholesterol fractionation. Given
the patient’s results provided below, what would be this patient’s LDL-C
status?
Total cholesterol = 400 mg/dL; triglycerides = 300 mg/dL; HDL-C = 100
mg/dL; LP electrophoresis, pending
a. High
b. Optimal
c. Desirable
d. Borderline
a. High
As part of a lipoprotein phenotyping, it is necessary to perform total
cholesterol and triglyceride determinations, as well as lipoprotein
electrophoresis. The test results obtained from such studies were
-Triglyceride, 340 mg/dL (reference range, <150 mg/dL)
-Total cholesterol, 180 mg/dL (reference range, <200 mg/dL)
-Pre–beta-lipoprotein fraction increased
-Beta-lipoprotein fraction normal
-No chylomicrons present
-Serum appearance turbid
The best explanation for these results would be that the patient exhibits a
phenotype indicative of
a. Type IV hyperlipoproteinemia
b. Type I hyperlipoproteinemia
c. Type II hyperlipoproteinemia
d. Type III hyperlipoproteinemia
e. Type V hyperlipoproteinemia
a. Type IV hyperlipoproteinemia
Which of the following results is the most consistent with high risk of CHD?
a. 20 mg/dL HDL-C and 250 mg/dL total cholesterol
b. 35 mg/dL HDL-C and 200 mg/dL total cholesterol
c. 50 mg/dL HDL-C and 190 mg/dL total cholesterol
d. 55 mg/dL HDL-C and 180 mg/dL total cholesterol
e. 60 mg/dL HDL-C and 170 mg/dL total cholesterol
a. 20 mg/dL HDL-C and 250 mg/dL total cholestero
What is the presumed defect in most cases of familial type IIa
hyperlipoproteinemia?
a. Defective receptors for LDL
b. Deficiency of hydroxymethylglutaryl (HMG)-CoA reductase
c. Deficiency of cholesterol esterase
d. Deficiency of LPL
e. Defective esterifying enzymes LCAT and ACAT
a. Defective receptors for LDL
Hyperchylomicronemia (type I) in childhood has been associated with which
of the following?
a. A deficiency of apo C-II
b. A deficiency of LCAT
c. A deficiency of LPL
d. A deficiency of apo A-I
a. A deficiency of apo C-II
