Calcium Homeostasis and Hormonal Regulation Flashcards
True or false? PTH and 1,25(OH)2D (vitamin D) are the principal hormones
involved in the normal physiologic regulation of calcium homeostasis.
True
The primary organs involved in the maintenance of calcium homeostasis are
the intestine, _____, and kidney.
Bone
Skin, _____, and kidneys are involved in the production of the active
metabolite of vitamin D.
Liver
True or false? Cod liver oil (ugh!) is a source of vitamin D.
True
True or false? 1,25(OH)2D is the best blood test for determining adequacy of
vitamin D stores in the body
False
True or false? PTHrP is produced by some cancers and often leads to cancerassociated hypercalcemia.
True
True or false? 1,25(OH)2D, due to 1-hydroxylase activity in macrophages,
may be produced to excess in granulomatous diseases and lymphoid
disorders, leading to hypercalcemia.
False
In PHPT, the defect primarily lies in _____. In secondary
hyperparathyroidism, the defect primarily lies with the threat of _____ to
the body.
parathyroid, hypocalcemia
Development of _____ _____ is the primary complication of hypercalciuria
(increased urinary excretion of calcium).
kidney stones
_____ _____ is the most common cause of hypoparathyroidism.
neck surgery
_____ is a type of bone most rapidly lost in response to hypogonadism and
glucocorticoid therapy
trabecular bone
_____ cells in bone are responsible for bone resorption, and _____ cells are
responsible for bone formation.
osteoclasts, osteoblasts
_____ is the most prevalent metabolic bone disease in the United States.
osteoporosis
True or false? Hormone replacement does not inhibit bone resorption in
osteoporotic patients
False
True or false? Teriparatide is the only drug currently approved by the FDA
for the treatment of osteoporosis that directly stimulates bone formation
(i.e., it is not an antiresorptive drug).
True
