Laboratory Markers of Cardiac Damage and Function

Question 1

A serum TnT concentration is of most value to the patient with an MI when
a. The CK-MB has already peaked and returned to normal concentrations
b. The onset of symptoms is within 3 to 6 hours of the sample being
drawn
c. The myoglobin concentration is extremely elevated
d. The TnI concentration has returned to normal concentrations

Answer 1

a. The CK-MB has already peaked and returned to normal concentrations

Question 2

A normal myoglobin concentration 8 hours after the onset of symptoms of a
suspected MI will
a. Essentially rule out an acute MI
b. Provide a definitive diagnosis of acute MI
c. Be interpreted with careful consideration of the TnT concentration
d. Give the same information as a total CK-MB

Answer 2

c. Be interpreted with careful consideration of the TnT concentration

Question 3

Which of the following analytes has the highest specificity for cardiac injury?
a. TnI
b. CK-MB mass assays
c. Total CK-MB
d. AST

Answer 3

a. TnI

Question 4

Which of the following newer markers of inflammation circulates in serum
bound to LD and HDL?
a. Lipoprotein-associated phospholipase A2
b. CK-MB
c. cTnI
d. hsCRP

Answer 4

a. Lipoprotein-associated phospholipase A2

Question 5

A person with a confirmed blood pressure of 125/87 would be classified as
a. Prehypertension
b. Normal
c. Stage 1 hypertension
d. Stage 2 hypertension

Answer 5

a. Prehypertension

Question 6

Rheumatic heart disease is a result of infection with which of the following
organisms?
a. Group A streptococci
b. Staphylococcus aureus
c. Pseudomonas aeruginosa
d. Chlamydia pneumoniae

Answer 6

a. Group A streptococci

Question 7

Which of the following defects is the most common type of congenital CVD
encountered?
a. Ventricular septal defects (VSD)
b. Tetralogy of Fallot
c. Coarctation of the aorta
d. Transposition of the great arteries

Answer 7

a. Ventricular septal defects (VSD)

Question 8

Which of the following cardiac markers is the most useful indicator of
congestive heart failure?
a. BNP
b. TnI
c. CK-MB
d. Glycogen phosphorylase isoenzyme BB

Answer 8

a. BNP

Question 9

Which of the following is the preferred biomarker for the assessment of
myocardial necrosis?
a. CK
b. AST
c. CK-MB
d. TnI

Answer 9

a. CK

Question 10

Which of the following is NOT a feature of an ideal cardiac marker?
a. Ability to predict future occurrence of cardiac disease
b. Absolute specificity
c. High sensitivity
d. Close estimation of the magnitude of cardiac damage

Answer 10

a. Ability to predict future occurrence of cardiac disease