TOPIC 2 Flashcards
Australian Poison Classification Schedule
Schedule 2
Schedule 3
7 Rights of Drug Administration
- Right person
- right medication
- right dose
- right route
- right time
- right documentation
- right reason
Definition Pharmacology
Study of history, physical and chemical properties of drugs/medicines.
How medications affect living systems
Definition Medication
Substances used for diagnosis, treatment, cure, relief and/or prevent illness/disease
Definition Pharmacodynamics
Study of the biochemical, physiological and molecular effects of medication
Definition Pharmacokinetics
Study of absorption, distribution, metabolism and excretion of medication
Definition Pharmacogenetics
Study of genetic factors that influence how a medication works on an individual
Routes of medication administration
Oral - PO
- easiest, prolonged effect
- slower onset, limited by gastric and liver breakdown
Sublingual (SL or subling)
- quickly absorbed, quick onset
- mistakenly swallowed or washed down with fluids
Buccal
- quickly absorbed, quick onset
- mistakenly swallowed or washed down with fluids, oral irritation
Inhaled
- large area of absorbency, rapid onset
- good technique, short effect
Eye
- easily administered
- good technique required
Nasal
- locally effective
- ineffective if over-sued
Ear
- locally effective
- good technique required
Topical
- prolonged effect
- easily removed
Rectal
- very effective
- consumer resistance
Vaginal
- good local effect
- consumer resistance
Medication consideration of the older adult
Altered drug receptor interaction
- Brain receptors become more sensitive
- drugs become potent
Altered metabolism
- liver mass shrinks
- enzymes lose ability to process some drugs - prolonging drug half-life
Altered absorption
- gastric emptying rate and GIT motility slow
Altered circulation
- vascular nerve control is less stable (dropping BP/HR etc)
Altered excretion
- Blood flow and waster removal slow
- drugs stay in the body longer
Distribution
- lean body mass falls
- adipose stores increase
Simple analgesia (PARACETAMOL) - mode of action
dose
effects
M - Activated descending serotonergic pathways and inhibist prostglandin synthesis
D - 1g 4x daily (max 4g)
E - nausea, dyspepsia
NSAIDS
(IBUPROFEN) -
mode of action
dose
effects
M - inhibits COX preventing production and release of prostaglandins
D - 220mg-400mg 6-8x daily (max 1200mg)
E - gastric irritation, bronchoconstriction
What is Pain
Nociceptors that are sensory receptors that detect signals from damaged tissue or the treat of damage
(noxious stimuli)
Where are nociceptors found?
Skin, muscle, joints, bone, viscera
What are the sources of pain?
Visceral
Somatic
Deep somatic
Cutaneous somatic
Referred pain
What is Visceral pain
- from direct injury/stretching of interior organs
- dull, deep, cramping
- poorly localised