Top Drawer- S3 Flashcards
Stimulation of GABAa receptors, high lipid solubility.
Uses: TIVA, induction, antiemetic, endoscopy, MAC.
Pain on injection-give w lidocaine
CV: decreased HR and BP, decreased SVR.
Decrease in CBF and ICP.
Propofol
Propofol can support bacteria how long is it good for open.
1. In opened vial infusion?
2. Drawn up in syringe?
12 hours infusion
6 hours syringe
Contraindications to Propofol?
Egg or soy allergies?
Patients with low CO or hypovolemia.
Will decrease HR and BP even more
Propofol dosing?
INDUCTION
MAC/MAINTENANCE
Propofol onset
Propofol Duration
Induction=2mg/kg
MAC=25-200mcg/kg/min
Onset= 30secs rapid
Duration= Dose dependent
Propofol metabolism?
In the liver to 4-hydroxypropofol
excreted in kidneys
Lidocaine is administered to?
1.Suppress coughing reflex during laryngoscopy
2.Reduce the airway responsiveness to noxious stimuli
3.Reduce pain caused by IV injection agents
Lidocaine dosing?
0.5-1mg/kg.
1mg/kg for induction
ERAS= 1-2 mcg/kg/hr
Which drug can attenuate the intracranial hypertensive response to laryngoscopy?
Lidocaine
Synthetic Piperidine
High volume of distribution in lipohillic opiods, low protein binding.
100x more potent than morphine
Metabolized by liver.
0.5-1mcg/kg (50-100mcgs) typically
Fentanyl
Which Opiod receptors does Fentanyl affect?
Mu-1
Mu-2
Kappa
Which opiod receptor affects?
Supraspinal analgesia
Bradycardia
Sedation
Pruritus
N/V
Mu-1
Morphine
Meperidine
Fentanyl
Which opiod receptor affects?
Respiratory depression
Euphoria
pruritis
constipation
dependence
Mu-2
Morphine
Meperidine
Fentanyl
Which opiod receptor affects?
Spinal analgesia
Respiratory depression
Sedation
miosis
Kappa
Fentanyl
Morphine
Nalbuphine
Which opiod receptor affects?
Spinal analgesia
Respiratory depression
Delta
Oxycodone
beta-endorphin
Leu-enkephalin
Noncompetitive NMDA receptor antagonist that blocks glutamate?
Phencyclidine derivative
Inhibits the re-uptake of Norepinephrine
Causes dissociative anesthesia
Given for induction, sedation, trauma, CV collapse.
Causes increase in BP, HR, CO, CVP, CI
Minimal respiratory depression, maintains airway reflexes, increased oral secretions, Bonchodilator
Emergence delirium (give versed)
Ketamine
Which opiod receptors does ketamine affect?
Kappa-agonist
Mu-antagonist
Increase in ICP, CBF, CMRO2,
Norketamine is active metabolite (1/3) potency.
Ketamine
Ketamine Dosing?
Onset?
Duration?
1-2mg/kg IV
4-5mg/kg IM
Onset-30 secs, IM-2 mins
Duration 10-15 mins
Short acting barbiturate
Activates GABA
Used in sedative, hypnotic, anticonvulsant, treatment of ICP in neuro cases.
Histamine release
Decrease CBP/ICP, hypotension.
No longer in the US
Thiopental
Short acting Barbiturate contraindicated in Acute Intermittent Porphyria (AIP).
Dosing 3-5 mg/kg IV
Onset- 30 secs
Duration- 5-30 mins
Hepatic metabolism
Thiopental
Ultrashort acting non-barbiturate hypnotic depressant RAS.
Affects GABA
used for induction or procedural sedation
Minimal CV effects, Minimal respiratory depression
Myoclonic Movements
Adrenocortical suppression (long-term)
Etomidate
Etomidate dosing?
Onset?
metabolism?
0.2-0.3 mg/kg
30-60 secs
Hepatic enzyme and plasma esterase hydrolysis
Highly selective, potent central acting Alpha-2 adrenergic agonist.
Inhibition of norepinephrine release presynaptically.
Used in procedure sedation, analgesia, fiberoptic intubation, post-op sedation.
Bradycardia/Hypotension
Minimal respiratory depression.
Dexmedetomidine
Dexmedetomidine dosing?
Onset?
Duration?
Excretion?
Procedural sedation: 0.5-1mcg/kg over 10 mins
IV infusion 0.3-0.7mcg/kg/hour.
5-10 min onset
duration 1 hour
Hepatic metabolism/urine excretion