Pathopharm 2 Exam 1 Qs!! Flashcards

1
Q

Which Glucocorticoid secreted by Adrenal Cortex?
A. Aldosterone
B. Cortisol
C. Cortisone
D. None

A

B. Cortisol

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2
Q

T/F: Glarine (Lantus) is a fast acting insulin that can be given IV?

A

False

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3
Q

T/F: 5 minutes is the half-life of elimination of endogenous insulin?

A

True

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4
Q

Which Inhibits Insulin Release?
A. Glucogon
B. Alpha agonist
C. Beta Adrenergic agonist
D. Glipizide
E. none

A

C. Beta Adrenergic agonist (inhibit the transport of insulin)

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5
Q

Which of the following is an incretin Analog:
A. Saxagliptin (Onglyza) – DPP-4 inhibitor
B. Canagliflozin (Invokana) – SGLT-2 inhibitor
C. Rosiglitazone (Avandia) – Thiazolidinediones
D. Miglitol (Glyset) – Meglitinide
E. None of the above

A

E. None of the above – Exenatide (Byetta)/Liraglutide (Victoza)/Albiglutide (Tanzeum)

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6
Q

Which oral hypoglycemic basically has no metabolism?

A

Metformin (Glucophage)

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7
Q

T/F: It is recommended Metformin be dc’d 48 hr prior to surgery?

A

True

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8
Q

Disease associated w/ Hypocortisolism:
A. Graves
B. Hashimoto
C. Conns
D. Cushings
E. None

A

E. None- Addisons

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9
Q

T/F: Dawn phenomenon characterized by increased blood glucose level in the early morning due to an increase in growth hormone?

A

True

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10
Q

Side Effects of Arginine Vasopressin all except?

A

Increased platelets
It actually decreases platelet count

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11
Q

Med used for Gout shown to be most useful?

A

Allopurinol

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12
Q

Which is Colchicine (Colcrys) MOA?
A. decreases pH
B. decreases absorption and increases excretion
C. none of the above

A
  • none of the above – it is a mitotic blocker
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13
Q

Which is least useful in treatment of RA?
A. NSAIDs
B. TNFs
C. ASA
D. Tylenol

A

D. Tylenol

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14
Q

T/F: Lesinurad (Zurampic) is a xanthine oxidase inhibitor?

A

False it is a uricosuric to increase urate excretion. It can only be used WITH a xanthine oxidase inhibitor-allopurinol

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15
Q

Which medication is a Chelator for RA treatment?

A

D- Penicilliamine (Cuprimine)

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16
Q

T/F: Syndactyly is an extra digit?

A

False it’s Webbing of fingers
Vestigial tabs- are extra digit

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17
Q

Term for immovable joint?

A

Synarthrosis

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18
Q

T/F: Ankylosing spondylitis is an autoimmune disease?

A

True

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19
Q

Which bone cells produce osteocalcin when stimulated by 1,25-dihydroxyvitamin D and synthesize osteoid?
a. Osteoclasts
b. Osteocytes
c. Fibrocytes
d. Osteoblasts

A

d. Osteoblasts

20
Q

Which structure attaches skeletal muscle to bone?
a. Tendon
b. Ligament
c. Bursa
d. Mesentery

A

a. Tendon

21
Q

T/F: Rhabdomyosarcoma is a tumor/malignancy of striated muscle?

A

True

22
Q

T/F: Peak bone mass is reached at mid 20 yrs old?

A

True, achieved in mid to late 20s

23
Q

What disease is associated w/ deficiency of vitamin D?

A

Rickets

24
Q

T/F: The development of tissue resistance to insulin leads to type 1 DM?

A

False, Type 2

25
Q

Which of the following statements is true regarding insulin?
a. acts on cells to decrease glucose uptake
b. produced primarily by adrenal glands
c. comprised of linked amino acids
d. newest forms come from guinea pigs
e. it is a dipeptide

A

c. Comprised of linked amino acids

26
Q

T/F: Gestational diabetes is from increased insulin secretion late in pregnancy?

A

False, decreased insulin

27
Q

T/F: Side effect of Plaquenil is Chrysiasis?

A

False, it is GOLD that causes it

28
Q

T/F: Paget disease can affect all bones, but it mainly affects appendicular skeleton?

A

False, its axial

29
Q

Which is least likely to treat gout?
a. Weight reduction
b. Decrease red meats
c. Increase fluid intake
d. Anti-hypercholesterolemia drugs

A

d. Anti-hypercholesterolemia drugs

30
Q

T/F: Best treatment for JIA is 30 minutes of solar time?

A

False,
No cure

31
Q

T/F: The use of humulin in the treatment of diabetes is associated with bovine spongiform?

A

False, no longer use

32
Q

T/F: Entercept (Enbrel) acts by inhibiting tumor necrosis factor TNF at its receptor?

A

True it is a TNF blocker

33
Q

T/F: Hyperparathyroidism leads to increase calcium and decreased phosphorous?

A

True

34
Q

Which PO hypoglycemics has been removed due to increased incidents of cardiac events?

A

Avandia
Causes MI

35
Q

T/F: Prolactin is synthesized by the anterior pituitary?

A

True

36
Q

T/F: The glucocorticoids are synthesized in the body from cholesterol?

A

True

37
Q

T/F: Conn disease is a disease of the anterior pituitary?

A

False, Conn disease is primary hyperaldosteronism from adrenal cortex

38
Q

T/F: Chlorpropamide (Diabinase) is a drug used in the treatment of gout that is also good for diabetes?

A

False, it is not used for Gout

39
Q

T/F: The posterior pituitary secretes oxytocin?

A

True

40
Q

T/F: Hashimoto is an AUTOIMMUNE disease?

A

True

41
Q

Parkinson disease is associated with defects in which area of the brain?
a. Thalamus
b. Medulla oblongata
c. Cerebellum
d. Substantia nigra

A

d. Substantia nigra

42
Q

T/F: Humulin N insulin contains protamine and zinc?

A

True

43
Q

T/F: Diabetes Insipidus is caused by decreased ability absorb water ascending loop of Henle?

A

False

44
Q

T/F: Ballismus is a form of extreme chorea?

A

True

45
Q

Which drug is an antimalarial used to treat RA?

A

Plaquenil

46
Q

Topamax treats all except ?

A

Neuropathic pain

47
Q

Precursor for Levodopa to prevent peripheral decarboxylation and extend half life?

A

Carbidopa (Lodosyn)