Pathopharm 2 Exam 1 Qs!! Flashcards
Which Glucocorticoid secreted by Adrenal Cortex?
A. Aldosterone
B. Cortisol
C. Cortisone
D. None
B. Cortisol
T/F: Glarine (Lantus) is a fast acting insulin that can be given IV?
False
T/F: 5 minutes is the half-life of elimination of endogenous insulin?
True
Which Inhibits Insulin Release?
A. Glucogon
B. Alpha agonist
C. Beta Adrenergic agonist
D. Glipizide
E. none
C. Beta Adrenergic agonist (inhibit the transport of insulin)
Which of the following is an incretin Analog:
A. Saxagliptin (Onglyza) – DPP-4 inhibitor
B. Canagliflozin (Invokana) – SGLT-2 inhibitor
C. Rosiglitazone (Avandia) – Thiazolidinediones
D. Miglitol (Glyset) – Meglitinide
E. None of the above
E. None of the above – Exenatide (Byetta)/Liraglutide (Victoza)/Albiglutide (Tanzeum)
Which oral hypoglycemic basically has no metabolism?
Metformin (Glucophage)
T/F: It is recommended Metformin be dc’d 48 hr prior to surgery?
True
Disease associated w/ Hypocortisolism:
A. Graves
B. Hashimoto
C. Conns
D. Cushings
E. None
E. None- Addisons
T/F: Dawn phenomenon characterized by increased blood glucose level in the early morning due to an increase in growth hormone?
True
Side Effects of Arginine Vasopressin all except?
Increased platelets
It actually decreases platelet count
Med used for Gout shown to be most useful?
Allopurinol
Which is Colchicine (Colcrys) MOA?
A. decreases pH
B. decreases absorption and increases excretion
C. none of the above
- none of the above – it is a mitotic blocker
Which is least useful in treatment of RA?
A. NSAIDs
B. TNFs
C. ASA
D. Tylenol
D. Tylenol
T/F: Lesinurad (Zurampic) is a xanthine oxidase inhibitor?
False it is a uricosuric to increase urate excretion. It can only be used WITH a xanthine oxidase inhibitor-allopurinol
Which medication is a Chelator for RA treatment?
D- Penicilliamine (Cuprimine)
T/F: Syndactyly is an extra digit?
False it’s Webbing of fingers
Vestigial tabs- are extra digit
Term for immovable joint?
Synarthrosis
T/F: Ankylosing spondylitis is an autoimmune disease?
True
Which bone cells produce osteocalcin when stimulated by 1,25-dihydroxyvitamin D and synthesize osteoid?
a. Osteoclasts
b. Osteocytes
c. Fibrocytes
d. Osteoblasts
d. Osteoblasts
Which structure attaches skeletal muscle to bone?
a. Tendon
b. Ligament
c. Bursa
d. Mesentery
a. Tendon
T/F: Rhabdomyosarcoma is a tumor/malignancy of striated muscle?
True
T/F: Peak bone mass is reached at mid 20 yrs old?
True, achieved in mid to late 20s
What disease is associated w/ deficiency of vitamin D?
Rickets
T/F: The development of tissue resistance to insulin leads to type 1 DM?
False, Type 2
Which of the following statements is true regarding insulin?
a. acts on cells to decrease glucose uptake
b. produced primarily by adrenal glands
c. comprised of linked amino acids
d. newest forms come from guinea pigs
e. it is a dipeptide
c. Comprised of linked amino acids
T/F: Gestational diabetes is from increased insulin secretion late in pregnancy?
False, decreased insulin
T/F: Side effect of Plaquenil is Chrysiasis?
False, it is GOLD that causes it
T/F: Paget disease can affect all bones, but it mainly affects appendicular skeleton?
False, its axial
Which is least likely to treat gout?
a. Weight reduction
b. Decrease red meats
c. Increase fluid intake
d. Anti-hypercholesterolemia drugs
d. Anti-hypercholesterolemia drugs
T/F: Best treatment for JIA is 30 minutes of solar time?
False,
No cure
T/F: The use of humulin in the treatment of diabetes is associated with bovine spongiform?
False, no longer use
T/F: Entercept (Enbrel) acts by inhibiting tumor necrosis factor TNF at its receptor?
True it is a TNF blocker
T/F: Hyperparathyroidism leads to increase calcium and decreased phosphorous?
True
Which PO hypoglycemics has been removed due to increased incidents of cardiac events?
Avandia
Causes MI
T/F: Prolactin is synthesized by the anterior pituitary?
True
T/F: The glucocorticoids are synthesized in the body from cholesterol?
True
T/F: Conn disease is a disease of the anterior pituitary?
False, Conn disease is primary hyperaldosteronism from adrenal cortex
T/F: Chlorpropamide (Diabinase) is a drug used in the treatment of gout that is also good for diabetes?
False, it is not used for Gout
T/F: The posterior pituitary secretes oxytocin?
True
T/F: Hashimoto is an AUTOIMMUNE disease?
True
Parkinson disease is associated with defects in which area of the brain?
a. Thalamus
b. Medulla oblongata
c. Cerebellum
d. Substantia nigra
d. Substantia nigra
T/F: Humulin N insulin contains protamine and zinc?
True
T/F: Diabetes Insipidus is caused by decreased ability absorb water ascending loop of Henle?
False
T/F: Ballismus is a form of extreme chorea?
True
Which drug is an antimalarial used to treat RA?
Plaquenil
Topamax treats all except ?
Neuropathic pain
Precursor for Levodopa to prevent peripheral decarboxylation and extend half life?
Carbidopa (Lodosyn)
