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ANTIBIÓTICOS ANTIBACTERIANOS > TMP-SXT Trimetoprim-sulfametoxazol - CLOTRIMOXAZOL > Flashcards

TMP-SXT Trimetoprim-sulfametoxazol - CLOTRIMOXAZOL Flashcards

1
Q

sulfametoxazol se da a dosis fijas con

A

sulfametoxazol

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2
Q

dos fármacos que actpuan en pasos secuenciales de la vía de

A

una reacción enzimática obligada en las bacterias, metabolismo del folato

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3
Q

bacteria resistente a trimetroprima

A

campilobacter,

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4
Q

trimetroprim es una

que inhibe a

A

diaminopiridina

dihidrofolato reducatasa bacteriana

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5
Q

quién inhibe primero?

A

sulfonamida

trimetroprim

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6
Q

espectro útil

A 
nocardia
pneumocystis jirovecii
shigella
clamydia diphtheriae
N. meningitidis
cyclospora cayetanensis
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7
Q

farmacacinética:
sulfametoxazol

fracción de absorción:

A

80 a 90%

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8
Q

farmacacinética:
sulfametoxazol
unión a proteínas

A

70%

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9
Q

farmacacinética:
sulfametoxazol

metabolismo hepático

A

acetilación

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10
Q

farmacacinética:
sulfametoxazol

eliminación renal total

A

60%

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11
Q

farmacacinética:
sulfametoxazol

eliminación renal libre:

A

7 a 13

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12
Q

semivida:

farmacacinética:
sulfametoxazol

A

10 a 12 hrs

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13
Q

farmacacinética:
trimetroprim:

fracción de absorción:

A

85 a 90%

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14
Q

farmacacinética:
trimetroprim:

unión a proteínas

A

45%

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15
Q

farmacacinética:
trimetroprim:

metabolismo hepático

A

oxidación

hidroxilación

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16
Q

farmacacinética:
trimetroprim:

eliminación renal total

A

80%

17
Q

farmacacinética:
trimetroprim:

eliminación renal libre

A

17 a 42%

18
Q

farmacacinética:
trimetroprim:

semivida:

A

9 a 11 hrs

19
Q

usos terapéuticos

A

infecciones urinarias crónicas y recurrentes

cistitis aguda

prostatitis

20
Q

usos terapéuticos

infecciones respiratorias bacterianas:

A

exacerbaciones agudas de la bronquitis crónica, otitis media aguda en niños y sinusitis maxilar aguda (H. influenzae y S. pneumoniae)

21
Q

usos terapéuticos

infecciones respiratorias bacterianas neumonía por pneumocystis jirovecci en pxs con

A

SIDA

22
Q

usos terapéuticos

infecciones digestivas:

A

shigellosis

fiebre tifoidea (2 o 3 línea)
diarrea del viajero (e-coli)
23
Q

usos terapéuticos

infecciones por:

A

nocardia
brucella
listeria
legionella

ANTIBIÓTICOS ANTIBACTERIANOS (29 decks)

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