Tissue Plasminogen Activator Flashcards
1
Q
What is another name for tissue plasminogen activator
A
Altepase
2
Q
What is t-PA and how does it work
A
its a naturally occuring serine protease that activates plasminogen bound to fibrin-more rapid than the free form (directly converts plasminogen into plasmin)
3
Q
How is t-PA administered
A
its mostly given through IC
4
Q
Where is t-PA cleared and how rapidly
A
its cleared in the liver
5
Q
What is the half life of t-PA
A
5-10 min
6
Q
How is t-PA inhibited
A
circulating inhibitors: plasminogen activator inhibitor 1 and 2
7
Q
What is t-PA used for or indications
A
used to lyse thrombi during MI treatment, acute ischemic stroke, and PE
8
Q
When should t-PA be administered
A
4.5 hours after symptom onset
9
Q
What is a down side of t-PA
A
its very expensive; recombinant DNA technology
