Fondaparinux Flashcards
What is another name for fondaparinux
arixtra
Describe fondaparinux
its a new pentasaccharide anticoagulant that is purely synthetic derived
What is a benefit of fondaparinux
it has no variable biological activity
What are the indications for fondaparinux
use in deep vein thrombosis—> leading to pulmonary embolism in patients with hip fracture surgery and hip replacement surgery
What is the mechanism of fondiparinux
it selectively inhibits 10a by binding to antithrombin 3
how is fondiparinux administered
by SQ route
What is good about fondiparinux
it has a predictable pharmacokinetic profile
Compared to heparin what are some benefits and down sides to fondiparinux
it requires less monitoring that UF
it does not cause thrombocytopenia-doesn’t bind to factor 4
but it does not have an antidote
what are major side effects of fondiparinux
major bleeding
In what way is fondiparinux, contraindicated in patients
its contraindicated with patients with severe renal impairment such as less than 30mL/min
