Clopidogrel

Question 0

How is the clopidogrel turned into the active form

Answer 0

CYPP450 (2C19) enzyme turns it into the active form

Question 1

What is so special about plavix. Hint it’s similar to ticlopidine but wih a notable difference

Answer 1

It’s a prodrug but it has a slow onset

Question 2

What are some benefits when clopidogrel to ticlopidine

Answer 2

Not as toxic to body and less thrombocytopenia and neutropenia

Question 3

What surgery is this clopidogrel commonly used for. Hint same as ticlopidine

Answer 3

Coronary stent placement

Question 4

What is clopidogrel good at preventing when compared to aspirin

Answer 4

It’s good at preventing a second stroke just like ticlopidine. But it’s even better than aspirin for unstable angina

Question 5

What’s better for preventing ischemia with patients having unstable angina aspirin or clopidogrel

Answer 5

Clopidogrel or plavix

Question 6

What does clopidogrel have a black box warning

Answer 6

Some patients are poor CYP2C19 metabolizers and can’t turn it into an active drug. Therefore these people will be at risk for stroke and heart attack. There is some resistance to its effects

Question 7

Give the percentage on the variation of CYP2C19 gene in various ethnicities

Answer 7

Variation is found in 30% whites, 40% blacks and 55% East Asian of CYP2C19 gene

Question 8

What test can be done to determine the effects of clopidogrel

Answer 8

Genetic test with a therapeutic strategy