Rivaroxaban

Question 1

What is another name for Rivaroxaban

Answer 1

Xarelto

Question 2

What is the mechanism of Rivaroxaban

Answer 2

its a DIRECT factor Xa inhibitor

Question 3

How is it administered

Answer 3

orally, once per day

Question 4

What is the peak onset of Rivaroxaban

Answer 4

2.5-4 hours

Question 5

What Rivaroxaban approved to treat

Answer 5

deep vein thrombosis—> pulmonary embolism after hip/ knee replacement surgery

Question 6

What is a positive about Rivaroxaban

Answer 6

it does not affect the P450 system

Question 7

What is it a substrate for

Answer 7

3A4 and p-glycoprotein (anything that induces these may affect levels)

Question 8

What is the major side effect of Rivaroxaban

Answer 8

bleeding

Question 9

Who is contraindicated with this drug

Answer 9

those with increased bleeding, bleeding disorders
hypertension
retinopathy-damage and bleeding in eye

Question 10

What is the type of patient this is not recommended with

Answer 10

moderate to sever hepatic impairment less than 30mL/min

Question 11

Although there is no antidote for Rivaroxaban, what have studies show may be use (MAYBE!!)

Answer 11

factor 7a and prothrombin complex

Question 12

How can we monitor Rivaroxaban

Answer 12

we don’t it doesn’t need monitoring

Question 13

What is good about Rivaroxaban compared to lmwh and unfractionated heparin

Answer 13

its cost is low 8 dollars and don’t need to worry about heparin induced thrombocytopenia