Lepirudin Flashcards
1
Q
What is another name for Lepirudin
A
Refludan
2
Q
What is the mechanism of action for lepirudin
A
inhibits thrombin-factor 2a
3
Q
Where is lepirudin derived from
A
the saliva of a medicinal leech
4
Q
How is it administered
A
IV
5
Q
Who is this drug used/ indications
A
patients that have developed heparin induced thrombocytopenia
6
Q
Who should not used lepirudin
A
those patients with renal failure because it can bulid up in the kidney and lead to bleeding
7
Q
What type of monitoring is done with lepirudin
A
aPTT monitoring need to be 1.5-2x patients baseline
8
Q
What is a disadvantage of lepirudin
A
the body can develop an antibody and there is no antidote
