Tissue plasminogen activator Flashcards
1
Q
How does tissue plasminogen activator work?
A
It’s a serine protease that catalyses the conversion of plasminogen to plasmin, which promotes clot breakdown
2
Q
What are the indications for tissue plasminogen activator?
A
Acute MI, PE, acute ischaemic stroke
3
Q
What are the contraindications for tissue plasminogen activator?
A
Acute pancreatitis, aneurysm, aortic dissection, coagulation defects
4
Q
What are the drug interactions of tissue plasminogen activator?
A
Heparin and enoaxaparin (anticoagulants)
5
Q
What are the side effects of tissue plasminogen activator?
A
Haemorrhage, hypotension, angina, PE
