Thrombosis Flashcards
Where my thrombi form?
Lumen of the heart - MI
Arteries - ischaemic and embolism
Veins - lines of zahn / DVT
Capillaries - disseminated coagulation
What are the triggers of thrombosis ?
Infections, septicaemia, malaria, neoplasms, liver disease
What’s promotes thrombosis?
Abnormalities of the vessel wall, blood flow and blood constituents
What causes abnormalities of the vessel wall?
Atheroma in arteries
MI in heart
Trauma, inflam in veins
Inflam in capillaries
What causes abnormalities in the blood flow?
Arteries - turbulence, aneurysms, plaques, spasm
Heart - atrial fibrillation, aneurysms
Veins - local problem
What causes abnormalities of the blood constituents?
Multiple myeloma, increased viscosity
What is an embolism?
The transport of abnormal marital (solid liquid gas) by the blood stream and it’s impacting blood vessel
What are the types of emboli?
Thrombi, fat, gas, tumour, infection, vegetations, atheroma
What is shock?
Significant systemic reduction in tissue perfusion, resulting in decreased tissue oxygen and nutrients removed - tissue injury
What is hypovolaemic shock?
Haemorrhage - severe burns
What is cardiogenic shock?
Large acute MI - other cardiac disease
What is septic shock ?
Endotoxins gram -bacteria, exotoxin gram +
What is anaphylactic shock?
Allergic reaction
What is neurogenic shock?
Spinal cord trauma
What is obstructive shock?
Cardiac tamponade, PE
