Inflammation

Question 1

What is the inflammation response?

Answer 1

Host response to tissue damage, protective response

Question 2

What triggers inflammation?

Answer 2

Foreign body, infection, ischemia, injury, immune

Question 3

What is vascular permeability?

Answer 3

The blood vessel wall to open and increase flow

Question 4

What is cellular reaction?

Answer 4

Recruit leukocytes to area, neutro and macro ingest and kill bacteria

Question 5

What is margination?

Answer 5

White blood cells in the peripheral flow along lumen

Question 6

What is rolling?

Answer 6

Selectins inhibit white blood cells to roll

Question 7

What is adhesion?

Answer 7

Cytokines encourage this, white blood cells stop ad attach to endothelium

Question 8

What is transmigration?

Answer 8

White blood cells encouraged to pass through extra-vascular space

Question 9

Clinical signs if inflammation?

Answer 9

Redness, heat, swelling, pain, loss of function

Question 10

What are the signs and symptoms?

Answer 10

Fever, tachycardia, hypo-tension, raised WBC and CRP

Question 11

EXAMPLE: Peak age 10-30 years, central abdo pain migrates to right iliac fossa, worse on movement. N/V. Pyrexia, Raised HR, Raised WBC and CRP.

Answer 11

Acute appendicitis - Appendectomy - abbess.

Question 12

EXAMPLE: Swollen, hot, red joint. Unable to move limb from pain. Pyrexia, Tachycardia, raised WBC. Risk: Prosthetic, recent surgery, trauma, RA.

Answer 12

Septic arthritis - Joint aspirate, IV antibiotics, Sepsis 6

Question 13

EXAMPLE: Warm, swollen, sniff joints. Immune attack, healthy joint gets destroyed.

Answer 13

Rheumatoid arthritis - Steroids, DMARDS.