thrombosis Flashcards
what are the two types of thrombosis?
arterial and venous
what causes arterial thrombosis?
endothelium damage
what are some causes of endothelium damage?
smoking, high BP, high cholesterol, diabetes
what can endothelium damage cause?
atherosclerosis
how can an atherosclerotic plaque cause MI, stroke or angina?
recruitment of foamy macrophages
plaques form -> narrowing of artery
plaque ruptures -> blocks artery
what is the initial management of atherosclerosis?
prevent endothelium damage
what is secondary management of athersclerosis?
antiplatelets
why do we give antiplatelets?
primary haemostasis is a mechanism of plaques forming
what causes venous thrombosis?
stasis of blood
what causes stasis of the blood?
DVT, PE, AF
what can DVT, PE and AF causing stasis and therefore venous thrombosis lead to?
stroke
what are causes of blood stasis?
increased coagulation activity
decreased fibrinolytic activity
decreased anticoagulant activity
- anti-thrombin
- protein C and S - switch off factors 5 and 8
