haematological cancers Flashcards

1
Q

what are the types of haem cancers?

A

leukaemia -> ALL, AML, CLL, CML
lymphomas -> Hodgkin’s, non-Hodgkin
myeloma -> multiple myeloma

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2
Q

which types of haem cancers are monoclonal?

A

leukaemia

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3
Q

what does monoclonal mean?

A

forming a clone derived from an individual cell
ALL CELLS LOOK THE SAME

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4
Q

what is acute myeloid leukaemia (AML)?

A

proliferation with blocked differentiation/maturation

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5
Q

what will be seen on blood film?

A

large cells with high nucleus to cytoplasm ratio
large number of primitive myeloids + neutropenia, RBC penia, thrombocytopenia

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6
Q

what is a buzz word blood finding in a question for AML?

A

auer rods

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7
Q

what is acute lymphoblastic leukaemia?

A

proliferation with blocked differentiation/maturation

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8
Q

what will be seen on blood film of someone with ALL?

A

lots of lymphoid progenitors -> no B-cells or T-cells

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9
Q

how can ALL stop myeloid differentiation?

A

release of chemicals
lack of space in marrow

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10
Q

who is ALL most commonly seen in?

A

children

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11
Q

what will be seen under a microscope in ALL?

A

blast cells - 4/5 red cells fit in a blast for size

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12
Q

what is chronic myeloid leukaemia (CML)?

A

proliferation with preserved maturation

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13
Q

what will be seen on blood film in someone with CML?

A

lots of neutrophils, RBCs, platelets (thrombocytosis)

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14
Q

what will be seen under s microscope in someone with CML?

A

segmented nucleus = maturation preserved

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15
Q

what will be seen on blood film of someone with chronic lymphocytic leukaemia?

A

small mature B lymphocytes

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16
Q

what will be seen under a microscope in a patient with CLL?

A

1/2 red cells fit into the bigger cell

17
Q

what is a buzz word finding in a blood film of someone with CLL?

A

smear/smudge cells

18
Q

what can CLL cause?

A

autoimmune haemolysis and ITP
hypersplenism -> pancytopenia

19
Q

if CLL infiltrates the bone marrow what can it cause?

A

suppression of myeloid cells

20
Q

which cells and conditions are most likely to go into the lymph nodes?

A

lymphoid
lymphoBLASTIC leukaemia

21
Q
A