chemo drugs Flashcards
what type of drug is cyclophosphamide?
alkylating agent
how does cyclophosphamide work?
causes cross-linking in DNA
what are side effects of cyclophosphamide?
haemorrhagic cystitis
myelosuppression
transitional cell carcinoma
what type of drugs are bleomycin and anthracyclines?
cytotoxic antibiotics
how does bleomycin work?
degrades preformed DNA
what is a side effect of bleomycin?
lung fibrosis
how do anthracyclines work?
stabilises topoisomerase II
what are side effects of anthracyclines?
cardiomyopathy
what type of drugs are methotrexate and fluorouracil?
antimetabolite
what is a side effect of methotrexate?
myelosuppression
how does vincristine work?
inhibits formation of microtubules
what is a side effect of vincristine?
peripheral neuropathy
how does cisplatin work?
causes cross-linking of DNA
what is a side effect of cisplatin?
ototoxicity
how does hydroxyurea work?
inhibits ribonucleotide reductase
