method of diagnosing secondary haemostatic diseases

Question 1

what can cause thrombocytopenia?

Answer 1

decreased production
increased destruction

Question 2

what does it mean if there is thrombocytopenia due to decreased production?

Answer 2

marrow failure

Question 3

what should you look at if it’s marrow failure?

Answer 3

does the patient have B symptoms (symptomatic - affecting them) or is the patient >60

Question 4

what could it be if it’s thrombocytopenia due to increased destruction?

Answer 4

DIC
ITP
TTP
HUS
liver failure and/or hypersplenism

Question 5

what if there is only prolonged APTT or PTT, not both?

Answer 5

means only extrinsic or intrinsic pathway are affected

Question 6

what does it mean if it’s a prolonged APTT?

Answer 6

intrinsic pathway - factors 12, 11, 9, 8

Question 7

what conditions could it be if the intrinsic pathway is affected?

Answer 7

haemophilia A -> factor 8
haemophilia B -> factor 9
heparin therapy
VWD - carries factor 8 around

Question 8

what does it mean if it’s prolonged PTT?

Answer 8

extrinsic pathway - factor 7a

Question 9

what does it mean if both APTT and PTT are prolonged?

Answer 9

common pathway is affected