secondary haemostatic failure

Question 1

what is the method of transmission for haemophilia?

Answer 1

x-linked

Question 2

which clotting factor is affected in haemophilia A?

Answer 2

12

Question 3

which clotting factor is affected in haemophilia B?

Answer 3

9

Question 4

how does a patient with haemophilia present?

Answer 4

delayed bleeding
bleeding into joints

Question 5

what will be seen in investigations for haemophilia?

Answer 5

prolonged APTT
normal PTT

Question 6

what is the management for haemophilia?

Answer 6

substitute clotting factors
tranexamic acid for bleeds/surgery

Question 7

what else can be used for management of haemophilia A?

Answer 7

desmopressin
emicizumab

Question 8

what clotting factors are affected in warfarin therapy?

Answer 8

10, 9, 7, 2 (1972)

Question 9

how would a patient present?

Answer 9

on warfarin (duh)

Question 10

what would be seen on investigation?

Answer 10

prolonged PTT AND prolonged APTT

Question 11

what is the management?

Answer 11

stop warfarin
administer vitK and clotting factors (prothrombin complex concentrate

Question 12

what factors are affected in vit K deficiency?

Answer 12

10, 9, 7, 2 (1972)

Question 13

how would a patient with vit k deficiency present?

Answer 13

bile obstruction - jaundice

Question 14

what is the management?

Answer 14

give vit K (duh)

Question 15

what clotting factors are affected in DIC?

Answer 15

1, 2, 5, 8, 11

Question 16

how would a patient with DIC present?

Answer 16

trauma
septic

Question 17

what would be seen on investigation of a patient with DIC?

Answer 17

very prolonged APTT AND PTT
prolonged D-dimer

Question 18

what clotting factors does heparin affect?

Answer 18

2, 9, 10, 11

Question 19

what clotting factors are affected in liver disease?

Answer 19

1, 2, 5, 7, 9, 10, 11