chronic myeloid leukaemia Flashcards
1
Q
what is seen?
A
lots of neutrophils, RBCs and platelets
2
Q
what is it?
A
chronic phase of over-production followed by a blast crisis
3
Q
what is a blast crisis?
A
proliferation of immature cells similar to AML
4
Q
how do patients present?
A
gout
splenomegaly
priapism
hyper-metabolic syndrome
5
Q
what investigations are used?
A
normal/low Hb
thrombocytosis (inc. platelets)
inc. WCC
BRC-ABL1
6
Q
which genetic mutation can cause CML?
A
translocation between chromosome 9 and 22 (Philadelphia chromosome)
7
Q
A
