The xT report, clinical resources and tools

Question 1

What is the first thing that a clinician see’s when they look over a report?

Answer 1

The sequencing results. Which includes DNA and RNA detection.

Question 2

What are the Genomic variants included on the report:

Answer 2

Somatic: potentially actionable
Somatic: biologically relevant
Germline: pathogenic/likely pathogenic
Somatic: pertinent negative

Question 3

What immunotherapy markers are included on the report?

Answer 3

• TMB

- MSI status

Question 4

Are therapy indications and clinical trials reported on the report as well?

Answer 4

Yes

Question 5

FDA- Approved therapies on the report include:

Answer 5

• current diagnosis

- other indications

Question 6

What would be an example of a secondary report ?

Answer 6

IHC results: MMR, this would indicate presence of absence of the four mismatch repair proteins.

Question 7

What would indicate an “abnormal” result on this?

Answer 7

1 or more of the 4 proteins has abnormal or missing expression.

Question 8

What’s an example of another secondary report?

Answer 8

IHC results: PD-L1, this indicates PD-L1 expression as well as the cutoff levels for tumor types for FDA-approved diagnostic interpretation.

Question 9

Clinical resources and tools included for clinicians

Answer 9

• Clinical reporting decision support tool
• LENS analytics tool
• Clinical trials decision support tool
• Immunotherapy decision support tool