Optional Immunohistochemistry

Question 1

What is CAR T-cell therapy?

Answer 1

A way to get immune cells called “T cells” to fight cancer by changing them in the lab so that they can find and destroy the cancer cells. It’s known as a type of cell-based gene therapy because it alters the genes in the T-cell to help them attack cancer.

Question 2

T or F- More neoantigens produced by a tumor = higher chance cancer cells will be recognized and killed by immune cells?

Answer 2

True

Question 3

How many mismatch repair proteins are there?

Answer 3

4 total

Question 4

what are they?

Answer 4

1. ) MLH1
2. ) MSH2
3. ) MSH6
4. ) PMS2

Question 5

Do these have to show loss of expression for a tumor to be dMMR?

Answer 5

Yes

Question 6

dMMR /MSI-H tumors are likely to respond to checkpoint inhibitors, T or F?

Answer 6

True

Question 7

What was the first tumor-agnostic anti-cancer therapy called?

Answer 7

pembrolizumab

Question 8

what does it do?

Answer 8

covers dMMR/MSI-H tumors without regard to cancer type.