Overview of xT

Question 1

Why do we cople the test with RNA?

Answer 1

So we can get the full transcript. Get a bigger picture of what’s going on.

Question 2

How many genes are on the incidental germline panel?

Answer 2

65 and they are all part of the DNA sequence already. 65 out of 648 total.

Question 3

What are all of these genes linked to?

Answer 3

Hereditary cancer

Question 4

when would follow-up testing be recommended if an incidental germline variant is detected and what would that involve?

Answer 4

xG , validated germline test

Question 5

Difference between “incidental” germline finding and “true” germline finding

Answer 5

• True Gfinding is when you run the xG test. Finding by a validated test.
• Incidental, means that you were sequencing the tumor and while we were looking at the normal match, we found a germline finding.