The Histology of Bone

Question 1

What is stored in bone?

Answer 1

Calcium and phosphate ions

Question 2

Bone architecture

Answer 2

Solid compact bone on outside

Spongy (trabecular) inner bone on inside

Question 3

Sesamoid bones

Answer 3

Develop in tendons (patella)

Question 4

Shin splints

Answer 4

Medial tibial stress syndrome

Inflammation of periosteum

Question 5

Osteocytes

Answer 5

MAINTAIN bone matrix

“Bone is calcified connective tissue consisting of osteocyte cells…”

Question 6

Woven bone is weaker than lamellar bone

Answer 6

True

Woven is a temporary fix

Question 7

What triggers the making of bone cells?

Answer 7

BMP and CBFA1 (core binding factor alpha)

Question 8

Osteoblast→osteocyte

Answer 8

True

Question 9

Osteoclasts

Answer 9

Resorption of bone

Question 10

Osteoclast activity is regulated by what?

Answer 10

Calcitonin and PTH

Question 11

Compact bone remodeling occurs where?

Answer 11

In the osteon

Question 12

Osteoporosis

Answer 12

More bone is resorbed than is replaced

Question 13

Osteoblast vs Osteoclast

Answer 13

Osteoblast: makes new bone

Osteoclast: resorption of bone (releases Ca)

Question 14

Parathyroid hormone does what in regards to bones?

Answer 14

Promotes bone resorption via osteoclasts

Question 15

Calcitonin does what in regards to bones?

Answer 15

Stops osteoclasts

Question 16

Osteoid

Answer 16

Organic matrix of bone prior to calcification

Question 17

Osteomalacia

Answer 17

Gradual softening of bone due to failure of bone to calcify because lack of Vit D