Development of the Muscular System: Derivatives of the Mesodermal Layer

Question 1

Lateral Plate Mesoderm does NOT given rise to skeletal muscle

Answer 1

True

It gives rise to connective tissue and skeleton of limbs, smooth muscle, blood vessels

Question 2

What do HOX genes regulate?

Answer 2

Growth/differentiation

Question 3

Paraxial Mesoderm condenses to form what?

Answer 3

Somites

Question 4

Role of retinoid acid

Answer 4

Regulates boundaries of each somite

Highest concentration is at head and decreases to feet

Question 5

What controls the segmentation clock?

Answer 5

FGF8 and WNT3a

Higher conc. at feet, lower at head

Question 6

Sclerotome gives rise to what?

Answer 6

Cartilage, bone components of vertebral column

Question 7

Molecular regulation of Muscle Development involves what 2 TF’s?

Answer 7

MyoD and MYF5

Question 8

Caudal Dysplasia

Answer 8

Problems with development of Caudal Mesoderm

Significant association with maternal diabetes

Caudal regression syndrome—“club feet”

Question 9

Somatic

Answer 9

Wall of the body cavity (it’s the outside of a glass cup if it’s inside a box)

Question 10

Splanchnic

Answer 10

internal organs (inside of the glass cup if it’s inside a box)