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PATHO B1 > Thalassemia > Flashcards

Thalassemia Flashcards

1
Q

CF

A

-Severe anemia
-mongoloid/thalassaemic facies(read basis in notes)
-hepatosplenomegaly
other:recurrent inf,spontaneous fractures,hypersplenism,leg ulcer
transfused patients: secondary haemochromatosis,cirrhosis,arrythmia, cardiac failure

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2
Q

general blood parameter

A

Hb:2-6 g/dl
Hct,MCV,MCH,MCHC: severely dec
WBC:inc
platelet:n/dec fr massive splenomegaly

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3
Q

peripheral blood smear

A

severe microcytiv hypochromic anemia with anisopoikilocytosis
basophilic stripling
target cells
fragmented rbc
pencil cells
cells with cabot ring
numerous nucleated red cells

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4
Q

BM

A

Normoblastic erythroid hyperplasia
predominance of intermediate n late normoblast
inc iron due to inc dietary absorption n haemolysis

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5
Q

Hb electrophoresis

A

HBA: ABSENT
HBA2:N/INC
HBF:MARKED INC

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6
Q

HIGH PERFORMANCE CHROMATOGRAPHY

A

INC HBF

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7
Q

PRENATAL DIAGNOSIS

A

Molecular DNA analysis

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8
Q

biochem

A

bilirubin:inc
serum haptoglobin: marked dec
serum iron status:iron,ferritin,transferrin inc
TIBC: DEC

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PATHO B1 (16 decks)

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