carcinogenesis Flashcards
polycyclic aromatic hydrocarbons
-3,4-benzpyrene
T: lung cancer,skin cancer
-smoking
-repeated mineral oils exposure
aromatic amines
-beta-naphthylamine
T:bladder cancer
-rubber and dye workers
nitrosamines
T:gut cancer
Azo dyes
2-acetylaminoflourene
t: bladder and liver cancer
Alkylating agents
t:leukaemia
other organic chemicals
-vinyl cholride
liver angiosarcoma
-used in polyvinyl chloride manufacture
human papillomavirus
t: squamus cell carcinoma,cervical carcinoma
HPV 6 OR 11-BENIGN,spontaneous regression
HPV 16 & 18- high risk
Epstein-Barr virus
t: Burkitt lymphoma,Nasopharyngeal cancer
-req cofactor.probably malaria
Hepatitis B and C
t:hepatocellular carcinoma
Human herpes virus
t:kaposi sarcoma, lymphoma
-association with AIDS n KAPOSI
Human T-cell lymphotrophic virus-1
t:adult T cell leukemia/lymphoma
-endemic in southern Japan
Markel cell polyoma virus
Merkel cell carcinoma of skin
