megaloblastic anaemia Flashcards
1
Q
CF FOLATE/ B12 DEF
A
anaemia+jaundice
glossitis
neural tube defects
abnormal gonadal cell mitosis
2
Q
CF B12 DEF
A
peripheral neuropathy
degeneration of spinal cord
optic atrophy
psychiatric disorders
3
Q
CBC
A
dec Hb con.c
dec Hct
RBC count:n/dec
MCV:> 100 fl –indicate macrocytic anaemia, n:(82-98)
MCH inc
MCHC:N
Reticulocytopenia
dec/n total wbc
platelet:n/dec
Pancytopenia(severe)
4
Q
peripheral smear
A
Macroovalocytes (macrocytic anaemia)
hypersegmented neutrophils (>5 lobe)
Howell-Jolly bodies (nuclear remnant)
Cabot Rings
basophilic stripling in RBC
5
Q
BM
A
-Hypercellular
-megaloblast
-giant metamyelocytes:
leucopoiesis
megakaryopoiesis
6
Q
biochem
A
inc unconjugated bilirubin
LDH
refer notes for table
