chronic lymphocytic leukaemia (CLL)

Question 1

AP

Answer 1

N

Question 2

ORGAN INVOLMENT

Answer 2

LN,liver,spleen

Question 3

peripheral blood findings

Answer 3

-leucocytosis(99% nucleated cells are B cell origin small lymphocyte
-inc lymphocyte
-normocytic anaemia
-thrombocytopenia

Question 4

BM changes

Answer 4

hypercellular(small lymphocytes)

Question 5

immunotyping : HELP DIF FR B-CELL ORIGIN NON-HODGKIN LYMPHOMA

Answer 5

CD5,CD23,CD19

Question 6

CLINICAL PRESENTATION

Answer 6

-asymptomatic
-fatigue,weight loss,anorexia,
-generalized lymphadenopathy,hepatosplenomegaly
-hypogammaglobulinemia—> inc susceptibility to inf
-haemolytoc aneamia/ thrombocytopenia due to auto AB by non-neoplastic B cells

Question 7

prognosis

Answer 7

Richter syndrome—-> diffuse large B-cell lymphoma
-rapid enlarging mass in LN/spleen
- less than 1 yr survival

Question 8

neoplastic cells of CLL

Answer 8

-small,round nuclei
-highly condensed chromatin
-soccer ball chromatin pattern
- inconspicious nucleoli
-scant cytoplasm
-unique markers: CD5,CD23,CD19
-smudge cell/parachute cell